Pharmacogenetics and asthma: false hope or new dawn?

被引：17

作者：

Hall, I. P. ^{[1
]}

Sayers, I. ^{[1
]}

机构：

[1] Univ Nottingham Hosp, Div Therapeut & Mol Med, Nottingham NG7 2UH, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2007年 / 29卷 / 06期

基金：

英国惠康基金;

关键词：

asthma genetics;

D O I：

10.1183/09031936.00088206

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pharmacogenetic approaches provide the opportunity to improve prescribing for asthmatic patients in order to optimise efficacy and prevent side-effects. Currently, there are comprehensive data available on the extent of genetic variation in the human genome that will further this area of research. However, less is known about the functional consequences of many of the identified polymorphisms in genes whose products may predict drug efficacy. In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research.

引用

页码：1239 / 1245

页数：7