Copper nanoparticles catalyzed economical synthesis of 3-substituted isocoumarins from 2-chlorobenzoic acids/amides and 1,3-diketones

被引：10

作者：

Wang, Xiaowen ^{[1
]}

Wu, Chaolong ^{[1
]}

Sun, Youwen ^{[1
]}

Yao, Xiaoquan ^{[1
]}

机构：

[1] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Dept Appl Chem, Nanjing 210016, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 32期

基金：

中国国家自然科学基金;

关键词：

3-Substituted isocoumarins; Copper nanoparticles catalyzed; 2-Chlorobenzoic acids; 2-Chlorobenzoic amides; 1,3-Diketones; O-IODOBENZOIC ACID; TERMINAL ALKYNES; ZINC-CHLORIDE; PHTHALIDES; DERIVATIVES; HETEROANNULATION; GENERATION;

D O I：

10.1016/j.tetlet.2017.07.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper nanoparticles were utilized as a highly efficient catalyst for a facile and economical synthesis of 3 substituted isocoumarins with 2-chlorobenzoic acids and 1,3-diketones as starting materials. The copper nanoparticles catalyst showed highly catalytic activity for the 2-chloro-substituted substrates to afford 3 substituted isocoumarins in good to excellent yields. Furthermore, good catalytic activity was also observed when 2-chlorobenzoic amides were utilized as substrates instead of the benzoic acids. (C) 2017 Published by Elsevier Ltd.

引用

页码：3164 / 3167

页数：4

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