NIR-II light-responsive biodegradable shape memory composites based on cuprorivaite nanosheets for enhanced tissue reconstruction

Near-infrared (NIR) light-responsive shape-memory composites have shown great potential in various biomedical applications due to their amazing remote actuation property. However, most of them are bioinert and restricted in NIR-I biological window. Here, we developed a new biodegradable NIR-II-responsive shape memory composite by the incorporation of CaSiCu4O10 nanosheets (CUP NSs) into shape memory polymer of poly (D, Llactide-co-trimethylene carbonate) (PDLLA-co-TMC, denoted as PT). The as-prepared CUP/PT composites possessed outstanding shape memory performance upon low power NIR-II laser irradiation (1064 nm, 0.4 W.cm- 2), offering the possibility of deep-tissue applications. Moreover, due to the sustained release of bioactive Cu2+ and SiO44- ions, the composites exhibited strong stimulation of angiogenesis both in vitro and in vivo. Our work demonstrated the promising potential of CUP/PT composites as NIR-II light-responsive biomaterials with enhanced tissue reconstruction ability, especially for wound healing.