The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

被引：21

作者：

Benninger, Richard K. P. ^{[1
,2
]}

Dorrell, Craig ^{[3
]}

Hodson, David J. ^{[4
,5
,6
,7
]}

Rutter, Guy A. ^{[8
]}

机构：

[1] Univ Colorado, Dept Bioengn, Anschutz Med Campus, Aurora, CO 80045 USA

[2] Univ Colorado, Barbara Davis Ctr Childhood Diabet, Anschutz Med Campus, Aurora, CO 80045 USA

[3] Oregon Hlth & Sci Univ, Dept Pediat, Oregon Stem Cell Ctr, Pape Family Pediat Res Inst, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[4] Univ Birmingham, Inst Metab & Syst Res IMSR, Birmingham B15 2TT, W Midlands, England

[5] Birmingham Hlth Partners, Ctr Endocrinol Diabet & Metab, Birmingham B15 2TH, W Midlands, England

[6] Univ Birmingham, COMPARE, Nottingham, England

[7] Univ Nottingham Midlands, Nottingham, England

[8] Imperial Coll London, Dept Med, Sect Cell Biol & Funct Genom, London W12 0NN, England

来源：

CURRENT DIABETES REPORTS | 2018年 / 18卷 / 11期

关键词：

Beta cell; Type; 1; diabetes; Insulin; Heterogeneity; Transcriptomics; Imaging; ENDOPLASMIC-RETICULUM STRESS; INSULIN-SECRETION; INTERCELLULAR DIFFERENCES; GLUCOSE-TOLERANCE; T-CELLS; B-CELLS; ISLETS; PROTEIN; ONSET; MASS;

D O I：

10.1007/s11892-018-1085-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewTo discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.Recent FindingsA number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single-cell omics to study both healthy and diseased cellsfrom patients with both T1D and type 2 diabetes (T2D)have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta-cell subpopulations for insulin secretion.SummaryHeterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D.

引用

页数：9

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