Glycosyl flavonoid profile, in vivo antidiabetic and in vitro antioxidant properties of Linaria reflexa Desf.

被引：12
作者：
Cheriet, Thamere [1 ,2 ]
Hanfer, Mourad [3 ]
Boudjelal, Amel [4 ]
Baali, Nadir [4 ]
Mancini, Ines [5 ]
Seghiri, Ramdane [1 ]
Ameddah, Souad [3 ]
Menad, Ahmed [3 ]
Benayache, Fadila [1 ]
Benayache, Samir [1 ]
机构：
[1] Univ Freres Mentouri Constantine BP, Unite Valorisat Ressources Nat Mol Bioact & Anal, Constantine, Algeria
[2] Univ MSila, Fac Sci, Dept Chim, Msila, Algeria
[3] Univ Freres Mentouri Constantine BP, Fac Sci Nat & Vie, Lab Biol & Environm, Constantine, Algeria
[4] Univ MSila, Fac Sci, Dept Microbiol & Biochim, Msila, Algeria
[5] Univ Trento, Lab Chim Bioorgan, Povo, Italy
来源：
NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 17期
关键词：
Linaria reflexa; HPLC-DAD-ESI/MS; antidiabetic; antioxidant; isolinariin D; isolinariin E;
D O I：
10.1080/14786419.2016.1274889
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Aerial parts of Linaria reflexa, used in North African folk medicine for treating certain skin diseases, were investigated by HPLC-DAD-ESI/MS technique able to identify the glycosyl flavonoids pectolinarin (1), isolinariin A (2), isolinariin B (3), linariin (4), isolinariin D (5) and isolinariin E (6) as the most abundant components in both hydroalcoholic (HAE) and ultrasound-assisted (UAE) extracts profiles. Metabolite 5, isolated and fully characterised by extensive nuclear magnetic resonance (NMR) analysis, has been very recently reported from L. japonica together with the compound 6. Good antioxidant activities (DPPH radical scavenging, beta-carotene bleaching and reducing power assays) were observed for the extracts. The remarkable antidiabetic activity displayed by UAE (300mg/kg) has yielded the most marked decrease in blood glucose levels of the alloxan diabetic rats (-72.09%), greater than the effects by the drug glybenclamide (-63.29%). This study reports the first correlation of antidiabetic activity of Linaria sp. extracts with their chemical composition.
引用
收藏
页码：2042 / 2048
页数：7
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