Stereoselective Total Synthesis of Cladospolide A

被引：18

作者：

Rajesh, Karuturi ^{[1
]}

Suresh, Vangaru ^{[1
]}

Selvam, Jondoss Jon Paul ^{[1
]}

Rao, Chitturi Bhujanga ^{[1
]}

Venkateswarlu, Yenamandra ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2010年 / 08期

关键词：

stereoselective synthesis; zinc mediator; allylations; aldol coupling; ring-closing metathesis; 1ST TOTAL-SYNTHESIS; PHYTOTOXIC MACROLIDE; ASYMMETRIC-SYNTHESIS; CHIRAL SULFOXIDES; AQUEOUS-MEDIA; CLADOSPORIOIDES;

D O I：

10.1055/s-0029-1219236

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and highly efficient stereoselective total synthesis of cladospolide A, a polyketide natural product, has been achieved. The synthesis involves stereoselective zinc-mediated allylation, pivotal aldol coupling, and ring-closing metathesis. The pivotal aldol coupling is used for the first time for macrolide construction and provides an effective alternative to Yamaguchi macrolactonization.

引用

页码：1381 / 1385

页数：5

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