Obtaining value from the human genome: a challenge for the pharmaceutical industry

被引：7
作者：
Spence, P [1 ]
机构：
[1] Wyeth Ayerst Res, CNS Disorders Div, Princeton, NJ 08543 USA
来源：
DRUG DISCOVERY TODAY | 1998年 / 3卷 / 04期
关键词：
D O I：
10.1016/S1359-6446(97)01162-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In a relatively short period of time, the sequence of the entire human genome and the identity of the genes contained within it will be determined. Among this vast array of genes are the pharmaceutical targets of the future, To benefit fully from this explosion of data, the pharmaceutical industry must establish high-throughput target identification and validation processes to feed their development pipelines.
引用
收藏
页码：179 / 188
页数：10
相关论文
共 65 条
[1]  
[Anonymous], 1994, The G-Protein linked Receptor Fact Book
[2]  
ANTEQUERA F, 1994, NAT GENET, V8, P114, DOI 10.1038/ng1094-114a
[3]   Are ESTs patentable? [J].
Auth, DR .
NATURE BIOTECHNOLOGY, 1997, 15 (09) :911-912
[4]   Yeast genes and human disease [J].
Bassett, DE ;
Boguski, MS ;
Hieter, P .
NATURE, 1996, 379 (6566) :589-590
[5]   HUNTING FOR GENES IN COMPUTER-DATA BASES [J].
BOGUSKI, MS .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (10) :645-647
[6]   Go hunting in sequence databases but watch out for the traps [J].
Bork, P .
TRENDS IN GENETICS, 1996, 12 (10) :425-427
[7]   CHARACTERIZATION OF THE PUFFERFISH (FUGU) GENOME AS A COMPACT MODEL VERTEBRATE GENOME [J].
BRENNER, S ;
ELGAR, G ;
SANDFORD, R ;
MACRAE, A ;
VENKATESH, B ;
APARICIO, S .
NATURE, 1993, 366 (6452) :265-268
[8]   A defect in nurturing in mice lacking the immediate early gene fosB [J].
Brown, JR ;
Ye, H ;
Bronson, RT ;
Dikkes, P ;
Greenberg, ME .
CELL, 1996, 86 (02) :297-309
[9]  
Campbell IL, 1996, MOL PSYCHIATR, V1, P105
[10]   Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death [J].
Chinnaiyan, AM ;
ORourke, K ;
Lane, BR ;
Dixit, VM .
SCIENCE, 1997, 275 (5303) :1122-1126
1234567