Current management of mucosal melanoma of the head and neck

被引:79
作者
Medina, JE
Ferlito, A
Pellitteri, PK
Shaha, AR
Khafif, A
Devaney, KO
Fisher, SR
O'Brien, CJ
Byers, RM
Robbins, KT
Pitman, KT
Rinaldo, A
机构
[1] Univ Udine, Policlin Univ, Dept Otolaryngol Head & Neck Surg, I-33100 Udine, Italy
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Otolaryngol, Oklahoma City, OK USA
[3] Geisinger Med Ctr, Dept Otolaryngol Head & Neck Surg, Danville, PA 17822 USA
[4] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, New York, NY 10021 USA
[5] Tel Aviv Sourasky Med Ctr, Dept Otorhinolaryngol, Tel Aviv, Israel
[6] Foote Hosp, Dept Pathol, Jackson, MI USA
[7] Duke Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Durham, NC USA
[8] Royal Prince Alfred Hosp, Dept Head & Neck Surg, Newtown, Tas, Australia
[9] Univ Texas, MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA
[10] Univ Mississippi, Med Ctr, Dept Otolaryngol, Jackson, MS 39216 USA
关键词
mucosal melanoma; head and neck cancer; immunohistochemistry; neck dissection;
D O I
10.1002/jso.10247
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
While mucosal-based melanomas of the head and neck region are uncommon lesions, when they do arise they usually follow an inexorably aggressive course. Experience with these tumors is, necessarily, limited; as such, well-worked out treatment protocols for the treatment of such lesions are in short supply. It appears as though mucosal melanomas (MuMs) develop more frequently in the nasal cavity and paranasal sinus region, and less often in the oral cavity. It seems that the incidence of nodal metastasis is significantly lower for sinonasal MuMs than it is for MuMs of the oral cavity; this observation may influence decisions about performing neck dissection as a function of location of the primary MuM. At present, surgical excision remains the mainstay of treatment; however, anatomical complexities within the region can hamper attempts at complete excision. Radiotherapy has not traditionally been relied on for routine treatment of MuM, although some recent reports have challenged this view. Chemotherapy is, at present, employed principally in the treatment of disseminated disease and for palliation. As a diagnostic matter, MuM belongs to the class of tumors that, on light microscopy, may with some regularity be confused with other malignancies (including sarcomas, plasmacytomas, and carcinomas); as a consequence, this is a diagnosis which is often best confirmed by way of ancillary testing via immunohistochemical studies. A better grasp of the best means of treating MuM will likely come only when large referral centers are able to pool their experiences with these uncommon yet virulent malignancies. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:116 / 122
页数:7
相关论文
共 51 条
  • [1] ANDERSEN LJ, 1992, J OTOLARYNGOL, V21, P180
  • [2] POSTOPERATIVE RADIOTHERAPY FOR CUTANEOUS MELANOMA OF THE HEAD AND NECK REGION
    ANG, KK
    PETERS, LJ
    WEBER, RS
    MORRISON, WH
    FRANKENTHALER, RA
    GARDEN, AS
    GOEPFERT, H
    HA, CS
    BYERS, RM
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 30 (04): : 795 - 798
  • [3] BERTHELSEN A, 1984, CANCER, V54, P907, DOI 10.1002/1097-0142(19840901)54:5<907::AID-CNCR2820540526>3.0.CO
  • [4] 2-Z
  • [5] Brandwein MS, 1997, ARCH OTOLARYNGOL, V123, P290
  • [6] Melan-A, a new melanocytic differentiation marker
    Busam, KJ
    Jungbluth, AA
    [J]. ADVANCES IN ANATOMIC PATHOLOGY, 1999, 6 (01) : 12 - 18
  • [7] Treatment of the neck in melanoma
    Byers, RM
    [J]. OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 1998, 31 (05) : 833 - +
  • [8] Chang AE, 1998, CANCER, V83, P1664, DOI 10.1002/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO
  • [9] 2-G
  • [10] CHAUDHRY AP, 1958, CANCER-AM CANCER SOC, V11, P923, DOI 10.1002/1097-0142(195809/10)11:5<923::AID-CNCR2820110507>3.0.CO