Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders

被引:1
作者
Ronan, Patrick J. [1 ,2 ,3 ]
Flynn, Sarah A. [2 ,3 ]
Beresford, Thomas P. [4 ,5 ]
机构
[1] Sioux Falls VA Res Serv, Sioux Falls, SD 57105 USA
[2] Sanford USD Sch Med, Dept Psychiat, Sioux Falls, SD USA
[3] Sanford USD Sch Med, Div Basic Biomed Sci, Sioux Falls, SD USA
[4] Rocky Mt Reg VA Med Ctr 116, Lab Clin & Translat Res Psychiat Res Serv & Psych, Aurora, CO USA
[5] Univ Colorado Denver, Sch Med, Dept Psychiat, Anschutz Med Campus, Aurora, CO USA
来源
MOLECULAR BASIS OF NEUROPSYCHIATRIC DISORDERS: FROM BENCH TO BEDSIDE | 2019年 / 167卷
关键词
TRAUMATIC BRAIN-INJURY; CORTICOTROPIN-RELEASING-FACTOR; POSTTRAUMATIC-STRESS-DISORDER; LIVER-TRANSPLANTATION; CYCLOSPORINE-A; BINDING-PROTEIN; SYNAPTIC PLASTICITY; MILITARY PERSONNEL; OXIDATIVE STRESS; MENTAL-HEALTH;
D O I
10.1016/bs.pmbts.2019.06.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Converging lines of evidence point to a significant role of neuroinflammation in a host of psychiatric conditions, including alcohol use disorder, TBI, and PTSD. A complex interaction of both peripheral and central signaling underlies processes involved in neuroinflammation. Calcineurin is a molecule that sits at the nexus of these processes and has been clearly linked to a number of psychiatric disorders including alcohol use disorder (AUD). Like its role in regulating peripheral immune cells, calcineurin (CN) plays an integral role in processes regulating neuroimmune function and neuroinflammatory processes. Targeting CN or elements of its signaling pathways at critical points may aid in the functional recovery from neuroinflammatory related disorders. In this review we will highlight the role of neuroinflammation and calcineurin signaling in AUD, TBI and stress-induced disorders and discuss recent findings demonstrating a therapeutic effect of immunosuppressant-induced calcineurin inhibition in a pre-clinical model of binge alcohol drinking.
引用
收藏
页码:125 / 142
页数:18
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