Stiff and Tight Skin: A Rear Window into Fibrosis Without Inflammation

被引：7

作者：

Avvedimento, Enrico V. ^{[1
]}

Gabrielli, Armando ^{[2
]}

机构：

[1] Univ Naples Federico II, Sch Med, Dept Biol & Patol Mol & Cellulare, Naples, Italy

[2] Univ Politecn Marche, Sez Clin Med, Dept Sci Med & Chirurg, Ancona, Italy

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2010年 / 2卷 / 23期

关键词：

GROWTH-FACTOR; MARFAN-SYNDROME; FIBRILLIN; MATRIX;

D O I：

10.1126/scitranslmed.3000949

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue of Science Translational Medicine, a report by Loeys et al. on mutations in the fibrillin-1 gene in patients with skin fibrosis (stiff skin) adds a new piece of information on a connective tissue disorder that resembles systemic sclerosis, an autoimmune disease characterized by skin fibrosis and visceral organ involvement. Here, we discuss the implications of these findings, as well as new opportunities for targeted therapy for fibrosis.

引用

页数：3

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