RGD-porphyrin conjugates: Synthesis and potential application in photodynamic therapy

被引：0
|
作者：
Chaleix, V
Sol, V
Huang, YM
Guilloton, M
Granet, R
Blais, JC
Krausz, P
机构：
[1] Univ Limoges, Fac Sci & Tech, Lab Chim Subst Nat, F-87060 Limoges, France
[2] Univ Paris 06, Lab Chim Struct Organ & Biol, CNRS UMR 7613, F-75252 Paris, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 08期
关键词：
glycosylation; photodynamic therapy; porphyrins; solid-phase synthesis;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a convenient solid-phase synthesis and characterisation of a new class of glycosylated porphyrins bearing the RGD tripeptide, designed for photodynamic cancer therapy. The photocytotoxicities of these compounds against the K562 leukemia cell line are also presented and compared to the effect of Photofrin II(R). ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
引用
收藏
页码：1486 / 1493
页数：8
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