The Anti-Leukemic Activity of Natural Compounds

被引：16

作者：

Cotoraci, Coralia ^{[1
]}

Ciceu, Alina ^{[2
]}

Sasu, Alciona ^{[1
]}

Miutescu, Eftimie ^{[3
]}

Hermenean, Anca ^{[2
,4
]}

机构：

[1] Vasile Goldis Western Univ Arad, Dept Hematol, Fac Med, Rebreanu 86, Arad 310414, Romania

[2] Vasile Goldis Western Univ Arad, Aurel Ardelean Inst Life Sci, Rebreanu 86, Arad 310414, Romania

[3] Vasile Goldis Western Univ Arad, Dept Gastroenterol, Fac Med, Rebreanu 86, Arad 310414, Romania

[4] Vasile Goldis Western Univ Arad, Dept Histol, Fac Med, Rebreanu 86, Arad 310414, Romania

来源：

MOLECULES | 2021年 / 26卷 / 09期

关键词：

antioxidants; flavonoids; anti-leukemic; myeloid leukemia; lymphoblastic leukemia; CHRONIC MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; RESVERATROL INDUCES APOPTOSIS; MITOCHONDRIA-MEDIATED APOPTOSIS; QUERCETIN-INDUCED APOPTOSIS; ORAL POLYPHENON E; K562; CELL-LINES; RAI STAGE 0; IN-VITRO;

D O I：

10.3390/molecules26092709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of biologically active compounds has become a realistic option for the treatment of malignant tumors due to their cost-effectiveness and safety. In this review, we aimed to highlight the main natural biocompounds that target leukemic cells, assessed by in vitro and in vivo experiments or clinical studies, in order to explore their therapeutic potential in the treatment of leukemia: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL). It provides a basis for researchers and hematologists in improving basic and clinical research on the development of new alternative therapies in the fight against leukemia, a harmful hematological cancer and the leading cause of death among patients.

引用

页数：29

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