Crystal structure of a 1:1 cocrystal of nicotinamide with 2-chloro-5-nitrobenzoic acid

被引：5
|
作者：
Bairagi, Keshab M. [1 ]
Pal, Priyanka [1 ]
Bhandary, Subhrajyoti [2 ]
Venugopala, Katharigatta N. [3 ,4 ]
Chopra, Deepak [2 ]
Nayak, Susanta K. [1 ]
机构：
[1] Visvesvaraya Natl Inst Technol, Dept Chem, Nagpur 440010, Maharashtra, India
[2] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal 462066, Madhya Pradesh, India
[3] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia
[4] Durban Univ Technol, Dept Biotechnol & Food Technol, ZA-4001 Durban, South Africa
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2019年 / 75卷
基金：
新加坡国家研究基金会;
关键词：
crystal structure; cocrystal; Hirshfeld surface; 2-chloro-5-nitrobenzoic acid; nicotinamide; PHARMACOKINETICS;
D O I：
10.1107/S2056989019013859
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In the title 1:1 cocrystal, C7H4ClNO4 center dot C6H6N2O, nicotinamide (NIC) and 2-chloro-5-nitrobenzoic acid (CNBA) cocrystallize with one molecule each of NIC and CNBA in the asymmetric unit. In this structure, CNBA and NIC form hydrogen bonds through O-H center dot center dot center dot N, N-H center dot center dot center dot O and C-H center dot center dot center dot O interactions along with N-H center dot center dot center dot O dimer hydrogen bonds of NIC. Further additional weak pi-pi interactions stabilize the molecular assembly of this cocrystal.
引用
收藏
页码：1712 / +
页数：12
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