High Serum Aβ and Vascular Risk Factors in First-Degree Relatives of Alzheimer's Disease Patients

被引:16
作者
Abdullah, Laila [1 ]
Luis, Cheryl [1 ]
Paris, Daniel [1 ]
Ait-ghezala, Ghania [1 ]
Mouzon, Benoit [1 ]
Allen, Elizabeth [2 ]
Parrish, Julia [1 ]
Mullan, Myles A. [1 ]
Ferguson, Scott [1 ]
Wood, Marcie [1 ]
Crawford, Fiona [1 ]
Mullan, Michael [1 ]
机构
[1] Roskamp Inst, Sarasota, FL 34243 USA
[2] London Sch Hyg & Trop Med, Dept Stat, London WC1, England
基金
美国国家卫生研究院;
关键词
HIGH-DENSITY-LIPOPROTEINS; PLASMA A-BETA-42; EPSILON-4; ALLELE; BLOOD-PRESSURE; DEMENTIA; PROTEIN; ONSET; PRESENILIN-1; POPULATION; PREDICTION;
D O I
10.2119/molmed.2008.00118
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The main objective of this study was to determine whether elevated blood beta-amyloid (A beta) levels among the first-degree relatives of patients with Alzheimer's Disease (AD) are associated with vascular risk factors of AD. Serum A beta was measured in samples from 197 cognitively normal first-degree relatives of patients with AD-like dementia, Study participants were recruited as part of an ancillary study of the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT subpopulation). The ADAPT subpopulation was found to be similar in age, sex, and ethnicity to another cognitively normal cohort (n = 98). Using cross-sectional analyses, we examined the association of A beta with blood pressure, lipid levels, apolipoprotein E genotypes, and the use of prescribed medication to treat vascular risk factors in the ADAPT subpopulation. A beta(1-40) was positively associated with age, use of antihypertensives, and serum creatinine, and we observed a marginal negative interaction on A beta(1-40) associated with systolic blood pressure and use of antihypertensives. Serum A beta(1-42) was associated with statin use and a positive correlation of A beta(1-42) with HDL was observed among statin nonusers. These findings suggest that high A beta in the periphery among the family history-enriched cohorts may be due to enrichment of vascular risk factors and may reflect presymptomatic AD pathology. It remains to be determined whether the association of A beta with medications used for treating vascular risk factors indicates prevention of AD. Longitudinal evaluation of blood A beta in this cohort will provide a better understanding of the significance of this association in AD etiology. (C) 2009 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: http://www.molmed.org doi: 10.2119/molmed.2008.00118
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页码:95 / 100
页数:6
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