Biomaterials Based on Carbon Nanotube Nanocomposites of Poly(styrene-b-isobutylene-b-styrene): The Effect of Nanotube Content on the Mechanical Properties, Biocompatibility and Hemocompatibility

被引:10
作者
Rezvova, Maria A. [1 ]
Nikishau, Pavel A. [2 ]
Makarevich, Miraslau I. [2 ,3 ]
Glushkova, Tatiana V. [1 ]
Klyshnikov, Kirill Yu. [1 ]
Akentieva, Tatiana N. [1 ]
Efimova, Olga S. [4 ]
Nikitin, Andrey P. [4 ]
Malysheva, Valentina Yu. [4 ]
Matveeva, Vera G. [1 ]
Senokosova, Evgeniia A. [1 ]
Khanova, Mariam Yu. [1 ]
Danilov, Viacheslav V. [5 ]
Russakov, Dmitry M. [6 ]
Ismagilov, Zinfer R. [4 ]
Kostjuk, Sergei V. [2 ,3 ,7 ]
Ovcharenko, Evgeny A. [1 ]
机构
[1] Res Inst Complex Issues Cardiovasc Dis, Dept Expt Med, Kemerovo 650002, Russia
[2] Belarusian State Univ, Res Inst Phys Chem Problems, Minsk 220006, BELARUS
[3] Belarusian State Univ, Dept Chem, Minsk 220006, BELARUS
[4] Fed Res Ctr Coal & Coal Chem SB RAS, Inst Coal Chem & Mat Sci, Kemerovo 650000, Russia
[5] Tomsk Polytech Univ, Res Lab Proc & Anal Big Data, Tomsk 634050, Russia
[6] Kemerovo State Univ, Inst Fundamental Sci, Kemerovo 650000, Russia
[7] Sechenov First Moscow State Med Univ, Inst Regenerat Med, Moscow 119991, Russia
基金
俄罗斯科学基金会;
关键词
single-walled carbon nanotubes; polymer nanocomposites; biocompatible polymers; interphase interaction; SIBS; cardiovascular medical devices; DISPERSION; FUNCTIONALIZATION; PERFORMANCE; POLYISOBUTYLENE; CYTOTOXICITY; DODECYLAMINE; COMPOSITES; FILLERS; WATER; FLOW;
D O I
10.3390/nano12050733
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanocomposites based on poly(styrene-block-isobutylene-block-styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a long non-polar alkane chain, provided much better dispersion of nanotubes in SIBS as compared to unmodified CNTs. As a result of such modification, the tensile strength of the nanocomposite based on SIBS with low molecular weight (M-n = 40,000 g mol(-1)) containing 4% of functionalized CNTs was increased up to 5.51 +/- 0.50 MPa in comparison with composites with unmodified CNTs (3.81 +/- 0.11 MPa). However, the addition of CNTs had no significant effect on SIBS with high molecular weight (M-n~70,000 g mol(-1)) with ultimate tensile stress of pure polymer of 11.62 MPa and 14.45 MPa in case of its modification with 1 wt% of CNT-DDA. Enhanced biocompatibility of nanocomposites as compared to neat SIBS has been demonstrated in experiment with EA.hy 926 cells. However, the platelet aggregation observed at high CNT concentrations can cause thrombosis. Therefore, SIBS with higher molecular weight (M-n~70,000 g mol(-1)) reinforced by 1-2 wt% of CNTs is the most promising material for the development of cardiovascular implants such as heart valve prostheses.
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页数:23
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