Multiple myeloma in cats: Variable presentation with different immunoglobulin isotypes in two cats

被引：19

作者：

Bienzle, D ^{[1
]}

Silverstein, DC ^{[1
]}

Chaffin, K ^{[1
]}

机构：

[1] Univ Guelph, Dept Pathobiol, Guelph, ON N1H 2W1, Canada

来源：

VETERINARY PATHOLOGY | 2000年 / 37卷 / 04期

关键词：

B cell neoplasia; monoclonal gammopathy; multiple myeloma;

D O I：

10.1354/vp.37-4-364

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficieny involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.

引用

页码：364 / 369

页数：6

共 18 条

[1] Multiple myeloma [J].

Bataille, R ;

Harousseau, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (23) :1657-1664

[2] IMMUNOGLOBULIN-PRODUCING TUMORS IN DOGS AND CATS [J].

BREUER, W ;

COLBATZKY, F ;

PLATZ, S ;

HERMANNS, W .

JOURNAL OF COMPARATIVE PATHOLOGY, 1993, 109 (03) :203-216

[3] MONOCLONAL GAMMOPATHY IN A DOG WITH CHRONIC PYODERMA [J].

BURKHARD, MJ ;

MEYER, DJ ;

ROSYCHUK, RA ;

ONEIL, SP ;

SCHULTHEISS, PC .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 1995, 9 (05) :357-360

[4]

CAROTHERS MA, 1989, J AM VET MED ASSOC, V195, P1593

[5]

Drazner F. H., 1982, Compendium on Continuing Education for the Practicing Veterinarian, V4, P206

[6] MONOCLONAL GAMMOPATHY IN A DOG WITH VISCERAL LEISHMANIASIS [J].

FONT, A ;

CLOSA, JM ;

MASCORT, J .

JOURNAL OF VETERINARY INTERNAL MEDICINE, 1994, 8 (03) :233-235

[7]

FORRESTER SD, 1992, J AM VET MED ASSOC, V200, P79

[8]

HAWKINS EC, 1986, J AM VET MED ASSOC, V188, P876

[9]

LARSEN AE, 1994, J AM VET MED ASSOC, V205, P708

[10] Long-term effects of localized spinal radiation therapy on vertebral fractures and focal lesions appearance in patients with multiple myeloma [J].

Lecouvet, F ;

Richard, F ;

VandeBerg, B ;

Malghem, J ;

Maldague, B ;

Jamart, J ;

Ferrant, A ;

Michaux, JL .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 96 (04) :743-745

← 1 2 →