Association of adiponectin polymorphisms with the risk of diabetic nephropathy in type 2 diabetes: A meta-analysis

ObjectiveAdiponectin gene polymorphisms have been reported to be associated with the risk of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. However, the results are inconsistent. MethodsElectronic literature databases and reference lists of relevant articles published until December 2013 were searched as part of a systematic review and meta-analysis to clarify the association between adiponectin gene polymorphisms and DN susceptibility in T2DM. Fixed- or random-effects models were used to calculate the effect sizes of odds ratio (OR) and 95% confidence intervals (95%CI). ResultsEleven case control studies were included. Overall, a significant association was observed for rs2241766T/G polymorphisms under the recessive model (GG vs TT+TG: OR 1.75; 95% CI 1.09-2.80; P=0.02). For rs17300539G/A, a significant association was observed under the GA vs GG model (OR 1.74; 95% CI 1.13-2.68; P=0.01) and A vs G allele model OR 1.65; 95% CI 1.13-2.41; P=0.009). After stratification by ethnicity, we found that the rs2241766 T/G dominant model (GG+TG vs TT: OR 1.52; 95% CI 1.12-2.07; P=0.007), heterozygous model (TG vs TT: OR 1.52; 95% CI 1.01-2.27; P=0.04) and G vs T allele (OR 1.50; 95% CI 1.07-2.10; P=0.02) may be associated with DN risk in the Caucasian population. For rs17300593G/A, the dominant model (GA+AA vs GG: OR 1.75; 95% CI 1.15-2.67; P=0.009) may be associated with DN risk in the Caucasian population. ConclusionAdiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.