Viral infections and asthma: an inflammatory interface?

被引：58

作者：

Oliver, Brian G. G. ^{[1
,2
]}

Robinson, Paul ^{[2
,3
,4
]}

Peters, Mathew ^{[5
,6
]}

Black, Judy ^{[2
]}

机构：

[1] Univ Technol Sydney, Sch Med & Mol Biosci, Sydney, NSW 2007, Australia

[2] Univ Sydney, Sydney Med Sch, Woolcock Inst Med Res, Sydney, NSW 2006, Australia

[3] Childrens Hosp Westmead, Dept Resp Med, Sydney, NSW, Australia

[4] Univ Sydney, Childrens Hosp Westmead, Sch Clin, Sydney, NSW 2006, Australia

[5] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia

[6] Concord Gen Hosp, Dept Thorac Med, Concord, Australia

来源：

EUROPEAN RESPIRATORY JOURNAL | 2014年 / 44卷 / 06期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; RHINOVIRUS; 16; INFECTION; EXHALED NITRIC-OXIDE; NEUTROPHILIC AIRWAY INFLAMMATION; RANDOMIZED CONTROLLED-TRIAL; BRONCHIAL EPITHELIAL-CELLS; COMMON COLD VIRUS; EARLY-LIFE; PHOSPHODIESTERASE-4; INHIBITOR; ANTIGEN BRONCHOPROVOCATION;

D O I：

10.1183/09031936.00047714

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma is a chronic inflammatory disease of the airways in which the majority of patients respond to treatment with corticosteroids and beta(2)-adrenoceptor agonists. Acute exacerbations of asthma substantially contribute to disease morbidity, mortality and healthcare costs, and are not restricted to patients who are not compliant with their treatment regimens. Given that respiratory viral infections are the principal cause of asthma exacerbations, this review article will explore the relationship between viral infections and asthma, and will put forward hypotheses as to why virus-induced exacerbations occur. Potential mechanisms that may explain why current therapeutics do not fully inhibit virus-induced exacerbations, for example, beta(2)-adrenergic desensitisation and corticosteroid insensitivity, are explored, as well as which aspects of virus-induced inflammation are likely to be attenuated by current therapy.

引用

页码：1666 / 1681

页数：16

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