Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action

被引：48

作者：

Lev, Avital ^{[1
]}

Princiotta, Michael F. ^{[2
]}

Zanker, Damian ^{[3
]}

Takeda, Kazuyo ^{[1
]}

Gibbs, James S. ^{[1
]}

Kumagai, Chiharu ^{[2
]}

Waffarn, Elizabeth ^{[1
]}

Dolan, Brian P. ^{[1
]}

Burgevin, Anne ^{[4
]}

Van Endert, Peter ^{[4
]}

Chen, Weisan ^{[3
]}

Bennink, Jack R. ^{[1
]}

Yewdell, Jonathan W. ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[2] SUNY Upstate Med Ctr, Dept Microbiol & Immunol, Syracuse, NY 13210 USA

[3] Austin Hlth, Ludwig Inst Canc Res, Cell Lab T, Melbourne Ctr Clin Sci, Heidelberg, Vic 3050, Australia

[4] Hop Necker Enfants Malad, INSERM, F-75743 Paris, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 15期

关键词：

MHC; peptide; translation; virus; CROSS-PRESENTATION; CYTOSOLIC PEPTIDES; PROTEIN-SYNTHESIS; DENDRITIC CELLS; DEGRADATION; MOLECULES; COMPLEX; GENE;

D O I：

10.1073/pnas.0910997107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MHC class I molecules function to display peptides generated from cellular and pathogen gene products for immune surveillance by CD8(+) T cells. Cells typically express similar to 100,000 class I molecules, or similar to 1 per 30,000 cellular proteins. Given "one protein, one peptide" representation, immunosurveillance would be heavily biased toward the most abundant cell proteins. Cells use several mechanisms to prevent this, including the predominant use of defective ribosomal products (DRiPs) to generate peptides from nascent proteins and, as we show here, compartmentalization of DRiP peptide generation to prevent competition from abundant cytosolic peptides. This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products.

引用

页码：6964 / 6969

页数：6

共 20 条

[1] Intracellular localization of proteasomal degradation of a viral antigen [J].