Albumin nanoparticles fabricated from microscaled PLGA templates using layer-by-layer assembly

被引：6

作者：

Zhao, Qi ^{[1
]}

Fang, Zhe-Xiang ^{[1
]}

Chen, Ming-Mao ^{[1
]}

Li, Min ^{[2
,3
]}

Zhou, Zhi-Min ^{[2
,3
]}

Du, Bo ^{[2
,3
]}

Zhang, Qi-Qing ^{[1
,2
,3
]}

机构：

[1] Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Fujian, Peoples R China

[2] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China

[3] Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R China

来源：

MICRO & NANO LETTERS | 2018年 / 13卷 / 06期

关键词：

proteins; nanoparticles; nanofabrication; self-assembly; particle size; drug delivery systems; biomedical materials; nanomedicine; elastic moduli; elastic modulus; external sonication; mechanical property; solid inner structure; spherical surface; hollow capsules; poly[lactic-co-(glycolic acid); drug delivery vehicles; layer-by-layer assembly; microscaled PLGA templates; albumin nanoparticles; MICROCAPSULES; PARTICLES; CAPSULES; DELIVERY; SYSTEMS;

D O I：

10.1049/mnl.2017.0696

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The size of particles is a principal parameter to design drug delivery vehicles. In this work, albumin nanoparticles were fabricated from microscaled poly[lactic-co-(glycolic acid)] (PLGA) templates using layer-by-layer (LbL) assembly, which are different from traditional LbL-based hollow capsules. The albumin nanoparticles exhibit a spherical shape and solid inner structure. The formation mechanism of these albumin nanoparticles was proposed based on PLGA templates, mechanical property of albumin and external sonication.

引用

页码：835 / 837

页数：3

共 15 条

[1] Emerging methods for the fabrication of polymer capsules [J].

Cui, Jiwei ;

van Koeverden, Martin P. ;

Muellner, Markus ;

Kempe, Kristian ;

Caruso, Frank .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2014, 207 :14-31

[2] Facile fabrication of gold particles decorated silk-on-silk nanocapsules [J].

Du, Bo ;

Wang, Hongwei ;

Tang, Hongbo ;

Guan, Man ;

Wang, Jingjie ;

Zhang, Zhe ;

Zhou, Zhimin ;

Zhang, Qiqing .

MATERIALS LETTERS, 2017, 187 :106-110

[3] Synthesis of silk-based microcapsules by desolvation and hybridization [J].

Du, Bo ;

Wang, Jingjie ;

Zhou, Zhimin ;

Tang, Hongbo ;

Li, Xuemin ;

Liu, Yingjie ;

Zhang, Qiqing .

CHEMICAL COMMUNICATIONS, 2014, 50 (34) :4423-4426

[4] Albumin nanostructures as advanced drug delivery systems [J].

Karimi, Mahdi ;

Bahrami, Sajad ;

Ravari, Soodeh Baghaee ;

Zangabad, Parham Sahandi ;

Mirshekari, Hamed ;

Bozorgomid, Mahnaz ;

Shahreza, Somayeh ;

Sori, Masume ;

Hamblin, Michael R. .

EXPERT OPINION ON DRUG DELIVERY, 2016, 13 (11) :1609-1623

[5] Drastic morphological modification of polyelectrolyte microcapsules induced by high temperature [J].

Köhler, K ;

Shchukin, DG ;

Sukhorukov, GB ;

Möhwald, H .

MACROMOLECULES, 2004, 37 (25) :9546-9550

[6] Silk fibroin layer-by-layer microcapsules for localized gene delivery [J].

Li, Linhao ;

Puhl, Sebastian ;

Meinel, Lorenz ;

Germershaus, Oliver .

BIOMATERIALS, 2014, 35 (27) :7929-7939

[7] High-Yield Fabrication of PLGA Non-Spherical Microarchitectures by Emulsion-Solvent Evaporation Method [J].

Li, Ruifeng ;

Li, Xuemin ;

Liu, Lingrong ;

Zhou, Zhimin ;

Tang, Hongbo ;

Zhang, Qiqing .

MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (22) :1981-1986

[8] Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release [J].

Luo, Guo-Feng ;

Xu, Xiao-Ding ;

Zhang, Jing ;

Yang, Juan ;

Gong, Yu-Hui ;

Lei, Qi ;

Jia, Hui-Zhen ;

Li, Cao ;

Zhuo, Ren-Xi ;

Zhang, Xian-Zheng .

ACS APPLIED MATERIALS & INTERFACES, 2012, 4 (10) :5317-5324

[9] Silk-based delivery systems of bioactive molecules [J].

Numata, Keiji ;

Kaplan, David L. .

ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (15) :1497-1508

[10] Ultrasonically induced opening of polyelectrolyte microcontainers [J].

Shchukin, Dmitry G. ;

Gorin, Dmitry A. ;

Moehwald, Helmuth .

LANGMUIR, 2006, 22 (17) :7400-7404

← 1 2 →