CD38/Cyclic ADP-ribose System: A New Player for Oxytocin Secretion and Regulation of Social Behaviour

被引：32

作者：

Salmina, A. B. ^{[1
]}

Lopatina, O. ^{[2
]}

Ekimova, M. V. ^{[1
]}

Mikhutkina, S. V. ^{[1
]}

Higashida, H. ^{[2
]}

机构：

[1] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk 660022, Russia

[2] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2010年 / 22卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

oxytocin; CD38; cyclic ADP-ribose; autism; social behaviour; METABOTROPIC GLUTAMATE RECEPTORS; MAGNOCELLULAR NEURONS; HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM; NEUROSECRETORY-SYSTEM; INTRACELLULAR CALCIUM; ADENINE-DINUCLEOTIDE; PERIPHERAL RELEASE; SUPRAOPTIC NEURONS; NERVE-TERMINALS; PEPTIDE RELEASE;

D O I：

10.1111/j.1365-2826.2010.01970.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oxytocin is important for regulating a number of physiological processes. Disruption of the secretion, metabolism or action of oxytocin results in an impairment of reproductive function, social and sexual behaviours, and stress responses. This review discusses current views on the regulation and autoregulation of oxytocin release in the hypothalamic-neurohypophysial system, with special focus on the activity of the CD38/cADP-ribose system as a new component in this regulation. Data from our laboratories indicate that an impairment of this system results in alterations of oxytocin secretion and abnormal social behaviour, thus suggesting new clues that help in our understanding of the pathogenesis of neurodevelopmental disorders.

引用

页码：380 / 392

页数：13

共 112 条

[91] Psychopharmacologic interventions for repetitive behaviors in autism spectrum disorders [J].

Soorya, Latha ;

Kiarashi, Jessica ;

Hollander, Eric .

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA, 2008, 17 (04) :753-+

[92] ATP ACTS AS FAST NEUROTRANSMITTER IN RAT HABENULA - NEUROCHEMICAL AND ENZYMECYTOCHEMICAL EVIDENCE [J].

SPERLAGH, B ;

KITTEL, A ;

LAJTHA, A ;

VIZI, ES .

NEUROSCIENCE, 1995, 66 (04) :915-920

[93] Local regulation of vasopressin and oxytocin secretion by extracellular ATP in the isolated posterior lobe of the rat hypophysis [J].

Sperlágh, B ;

Mergl, Z ;

Jurányi, Z ;

Vizi, ES ;

Makara, GB .

JOURNAL OF ENDOCRINOLOGY, 1999, 160 (03) :343-350

[94] Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors [J].

Ster, J ;

Colomer, C ;

Monzo, C ;

Duvoid-Guillou, A ;

Moos, F ;

Alonso, G ;

Hussy, N .

JOURNAL OF NEUROSCIENCE, 2005, 25 (09) :2267-2276

[95] Nitric oxide and homeostatic control: an intercellular signalling molecule contributing to autonomic and neuroendocrine integration? [J].

Stern, JE .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2004, 84 (2-3) :197-215

[96] Functional switching of GABAergic synapses by ryanodine receptor activation [J].

Sun, MK ;

Nelson, TJ ;

Alkon, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12300-12305

[97] Endogenous Cannabinoids take the edge off neuroendocrine responses to stress [J].

Tasker, J .

ENDOCRINOLOGY, 2004, 145 (12) :5429-5430

[98] Remodeling of astrocytes, a prerequisite for synapse turnover in the adult brain? Insights from the oxytocin system of the hypothalamus [J].

Theodosis, DT ;

Trailin, A ;

Poulain, DA .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 290 (05) :R1175-R1182

[99] OXYTOCIN INDUCES MORPHOLOGICAL PLASTICITY IN THE ADULT HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM [J].

THEODOSIS, DT ;

MONTAGNESE, C ;

RODRIGUEZ, F ;

VINCENT, JD ;

POULAIN, DA .

NATURE, 1986, 322 (6081) :738-740

[100] The actin filament and dendritic peptide release [J].

Tobin, V. A. ;

Ludwig, M. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 :1243-1246

← 3 4 5 6 7 8 9 10 11 12 →