CD38/Cyclic ADP-ribose System: A New Player for Oxytocin Secretion and Regulation of Social Behaviour

被引:32
作者
Salmina, A. B. [1 ]
Lopatina, O. [2 ]
Ekimova, M. V. [1 ]
Mikhutkina, S. V. [1 ]
Higashida, H. [2 ]
机构
[1] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk 660022, Russia
[2] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa, Japan
基金
俄罗斯基础研究基金会;
关键词
oxytocin; CD38; cyclic ADP-ribose; autism; social behaviour; METABOTROPIC GLUTAMATE RECEPTORS; MAGNOCELLULAR NEURONS; HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM; NEUROSECRETORY-SYSTEM; INTRACELLULAR CALCIUM; ADENINE-DINUCLEOTIDE; PERIPHERAL RELEASE; SUPRAOPTIC NEURONS; NERVE-TERMINALS; PEPTIDE RELEASE;
D O I
10.1111/j.1365-2826.2010.01970.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Oxytocin is important for regulating a number of physiological processes. Disruption of the secretion, metabolism or action of oxytocin results in an impairment of reproductive function, social and sexual behaviours, and stress responses. This review discusses current views on the regulation and autoregulation of oxytocin release in the hypothalamic-neurohypophysial system, with special focus on the activity of the CD38/cADP-ribose system as a new component in this regulation. Data from our laboratories indicate that an impairment of this system results in alterations of oxytocin secretion and abnormal social behaviour, thus suggesting new clues that help in our understanding of the pathogenesis of neurodevelopmental disorders.
引用
收藏
页码:380 / 392
页数:13
相关论文
共 112 条
  • [1] What is the role of astrocyte calcium in neurophysiology?
    Agulhon, Cendra
    Petravicz, Jeremy
    McMullen, Allison B.
    Sweger, Elizabeth J.
    Minton, Suzanne K.
    Taves, Sarah R.
    Casper, Kristen B.
    Fiacco, Todd A.
    McCarthy, Ken D.
    [J]. NEURON, 2008, 59 (06) : 932 - 946
  • [2] Regulation of intracellular levels of NAD: A novel role for CD38
    Aksoy, Pinar
    White, Thomas A.
    Thompson, Michael
    Chini, Eduardo N.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (04) : 1386 - 1392
  • [3] Calbindin D28k and calretinin in oxytocin and vasopressin neurons of the rat supraoptic nucleus - A triple-labeling immunofluorescence study
    Arai, R
    Jacobowitz, DM
    Hida, T
    [J]. CELL AND TISSUE RESEARCH, 1999, 298 (01) : 11 - 19
  • [4] Dopamine D4 receptor-mediated presynaptic inhibition of GABAergic transmission in the rat supraoptic nucleus
    Azdad, K
    Piet, R
    Poulain, DA
    Oliet, SHR
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (02) : 559 - 565
  • [5] BATZ JA, 2007, BIOESSAYS, V29, P837
  • [6] Stimulation of central and systemic oxytocin release by histamine in the paraventricular hypothalamic nucleus: Evidence for an interaction with norepinephrine
    Bealer, SL
    Crowley, WR
    [J]. ENDOCRINOLOGY, 1999, 140 (03) : 1158 - 1164
  • [7] MORPHOLOGICAL EVIDENCE FOR VESICULAR GLUTAMATE RELEASE FROM ASTROCYTES
    Bergersen, L. H.
    Glindersen, V.
    [J]. NEUROSCIENCE, 2009, 158 (01) : 260 - 265
  • [8] ENDOGENOUS OPIATES REGULATE OXYTOCIN BUT NOT VASOPRESSIN SECRETION FROM THE NEUROHYPOPHYSIS
    BICKNELL, RJ
    LENG, G
    [J]. NATURE, 1982, 298 (5870) : 161 - 162
  • [9] Sniffing neuropeptides: a transnasal approach to the human brain
    Born, J
    Lange, T
    Kern, W
    McGregor, GP
    Bickel, U
    Fehm, HL
    [J]. NATURE NEUROSCIENCE, 2002, 5 (06) : 514 - 516
  • [10] Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones
    Bruzzone, S
    Verderio, C
    Schenk, U
    Fedele, E
    Zocchi, E
    Matteoli, M
    De Flora, A
    [J]. JOURNAL OF NEUROCHEMISTRY, 2004, 89 (01) : 264 - 272