Synthesis, Crystal Structure and Anti-lung Cancer Activity of a New Dy(II) Complex

A new Dy-based coordination polymer, namely {[Dy(cptpy)(2)(H2O)(2)](TPT)(Cl)}(n) (1, Hcptpy = 4-(4-carboxyphenyl)-4,2':6', 4''-terpyridine, TPT = 2,4,6-tri(4-pyridyl)-1,3,5-triazine, DMA = N, N-dimethylacetamide) has been solvothermally synthesized by the reactions of DyCl3, Hcptpy and TPT in a mixture solvent of DMA and H2O. Single-crystal X-ray structural analysis reveals that 1 is a 1D linear chain coordination polymer with quadrangle channels which are occupied by the TPT ligands. The compound has been characterized by singe-crystal analyses, thermogravimetry analyses and powder X-ray diffraction measurements. The antitumor activity of compound 1 and its corresponding organic ligands Hcptpy and TPT were then investigated against four human lung cancer cell lines (NCI-H460, Calu-3, A549 and NCI-H292) by MTT assay. It was found that compared with Hcptpy and TPT, compound 1 exerted rather potent activity against all of these cell lines.