Toward a biological network for atherosclerosis

被引：37
作者：
Ghazalpour, A
Doss, S
Yang, X
Aten, J
Toomey, EM
Van Nas, A
Wang, S
Drake, TA
Lusis, AJ [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, Dept Human Genet, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
来源：
JOURNAL OF LIPID RESEARCH | 2004年 / 45卷 / 10期
关键词：
systems biology; transgenic mice; quantitative trait locus mapping; principal components; Bayesian networks; correlation coefficients; genetics; genomics; proteomics;
D O I：
10.1194/jlr.R400006-JLR200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. jlr In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks. -Ghazalpour, A., S. Doss, X. Yang, J. Aten, E. M. Toomey, A. Van Nas, S. Wang, T. A. Drake, and A. J. Lusis. Toward a biological network for atherosclerosis.
引用
收藏
页码：1793 / 1805
页数：13
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