Induction of ornithine decarboxylase mRNA in transient focal cerebral ischemia in the rat

被引：9

作者：

Keinänen, R ^{[1
]}

Miettinen, S ^{[1
]}

Yrjänheikki, J ^{[1
]}

Koistinaho, J ^{[1
]}

机构：

[1] Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland

来源：

NEUROSCIENCE LETTERS | 1997年 / 239卷 / 2-3期

关键词：

rat; focal cerebral ischemia; ornithine decarboxylase; mRNA induction; N-methyl-D-aspartate receptor;

D O I：

10.1016/S0304-3940(97)00890-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used in situ hybridization to localize the long-term changes in ornithine decarboxylase (ODC) expression after a 90 min occlusion of the middle cerebral artery (MCAO) in the rat. The ODC mRNA was induced in the ipsilateral dentate gyrus (DG) and throughout the ischemic cortex at 12 h and still at 3 days after reperfusion. The induction was blocked by an N-methyl-D-aspartate (NMDA) receptor antagonist suggesting that ODC induction is NMDA receptor-mediated. The long-lasting up-regulation detected in regions where no cellular damage usually occurs, favors the hypothesis that ODC expression does not contribute to neuronal death after stroke. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：69 / 72

页数：4

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