The chondrocyte

被引：236
作者：
Archer, CW
Francis-West, P
机构：
[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales
[2] Kings Coll London, Dept Craniofacial Dev, London SE10 9RT, England
[3] Cardiff Univ, Inst Tissue Engn & Repair, Cardiff CF10 3US, S Glam, Wales
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 04期
关键词：
cartilage; joint; matrix; arthritis;
D O I：
10.1016/S1357-2725(02)00301-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The chondrocyte is the resident cell of cartilage that is a prominent tissue in the embryo acting as a template for the development of skeletal elements. In the adult, the distribution of permanent cartilage is much more restricted and is necessary for mechanical support, growth and movement. The cell is isolated within a voluminous extracellular matrix (ECM) that is neither vascularised nor innervated. As a result, nutrient/waste exchange occurs through diffusion and, consequently, under normal and pathological conditions, the cell is unique in its ability to exist in a low oxygen tension environment. Partly as a result of these properties, the tissue has a low reparative potential that, in the case of articular cartilage, predisposes the tissue to degenerative conditions such as arthritis that is a significant clinical problem. Cellfacts Cytoplasmically isolated. High matrix/cell volume ratio. Do not divide after skeletal maturity unless during pathology. Major contributor to growth of the body. Most energy requirements obtained through glycolysis. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：401 / 404
页数：4
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