Stereoselective synthesis of a 2,3-disubstituted 5-pyrrolidinone derivative of quinazolin-4(3H)-one

被引：0
|
作者：
Szabo, M
Kokosi, J
Kovacs, A
Bocskei, Z
Hermecz, I
机构：
[1] Semmelweis Univ Med, Inst Pharmaceut Chem, H-1092 Budapest, Hungary
[2] Tech Univ, Dept Gen & Analyt Chem, H-1114 Budapest, Hungary
[3] Chinoin Chem & Pharmaceut Works Ltd, H-1325 Budapest, Hungary
来源：
HETEROCYCLES | 1997年 / 45卷 / 12期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Thermal cyclization of acetoacetamide (3), prepared from 2-[1'-(p-methoxyphenylaminoethyl]quinazolin-4(3H)-one (2) and ethyl acetoacetate, resulted in the formation of 2-(5-oxopyrrolidin-2-yl)quinazolin-4(3H)-one (6) with high selectivity in excellent yield. The stereostructure of 6 was investigated by NMR spectroscopy, and determined by X-Ray investigations.
引用
收藏
页码：2437 / 2442
页数：6
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