Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases

被引：44
作者：
Pan, Qin
Luo, Fengling
Liu, Min
Zhang, Xiao-Lian [1 ]
机构：
[1] Wuhan Univ, Sch Med, State Key Lab Virol, Donghu Rd 185, Wuhan 430071, Hubei, Peoples R China
来源：
JOURNAL OF INFECTION | 2018年 / 77卷 / 02期
基金：
中国国家自然科学基金;
关键词：
SELEX; Aptamer; Infectious disease; Diagnosis; Therapy; HEPATITIS-C-VIRUS; IN-VITRO SELECTION; MANNOSE-CAPPED LIPOARABINOMANNAN; NEUTRALIZES R5 STRAINS; RECEPTOR-BINDING REGION; STRANDED-DNA APTAMER; LABEL-FREE DETECTION; WHOLE-CELL-SELEX; RNA APTAMERS; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1016/j.jinf.2018.04.007
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets. These aptamers have an exciting potential for diagnose and/or treatment of specific diseases. In this review, we highlight areas where aptamers have been developed as diagnostic and therapeutic agents for both bacterial and viral infectious diseases as well as aptamer-based detection. (C) 2018 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：83 / 98
页数：16
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