In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

被引：34

作者：

Beedie, Shaunna L. ^{[1
,2
]}

Rore, Holly M. ^{[1
]}

Barnett, Shelby ^{[1
,4
]}

Chau, Cindy H. ^{[2
]}

Luo, Weiming ^{[3
]}

Greig, Nigel H. ^{[3
]}

Figg, William D. ^{[2
]}

Vargesson, Neil ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Sch Med Med Sci & Nutr, Foresterhill, Aberdeen, Scotland

[2] NCI, Mol Pharmacol Sect, Genitourinary Malignancies Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[3] NIA, Drug Design & Dev Sect, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA

[4] Univ Manchester, Manchester Pharm Sch, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England

来源：

ONCOTARGET | 2016年 / 7卷 / 22期

基金：

英国惠康基金;

关键词：

angiogenesis; inflammation; thalidomide; cancer; teratogenesis; NECROSIS-FACTOR-ALPHA; REFRACTORY MULTIPLE-MYELOMA; TNF-ALPHA; SYNTHESIS INHIBITOR; TRANSGENIC ZEBRAFISH; COGNITIVE DEFICITS; ALZHEIMERS-DISEASE; LIMB DEFECTS; ANGIOGENESIS; POMALIDOMIDE;

D O I：

10.18632/oncotarget.8909

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thalidomide, a drug known for its teratogenic side-effects, is used successfully to treat a variety of clinical conditions including leprosy and multiple myeloma. Intense efforts are underway to synthesize and identify safer, clinically relevant analogs. Here, we conduct a preliminary in vivo screen of a library of new thalidomide analogs to determine which agents demonstrate activity, and describe a cohort of compounds with anti-angiogenic properties, anti-inflammatory properties and some compounds which exhibited both. The combination of the in vivo zebrafish and chicken embryo model systems allows for the accelerated discovery of new, potential therapies for cancerous and inflammatory conditions.

引用

页码：33237 / 33245

页数：9

共 54 条

[51] Thalidomide-induced limb defects: resolving a 50-year-old puzzle [J].

Vargesson, Neil .

BIOESSAYS, 2009, 31 (12) :1327-1336

[52] Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy: new cases and review of the main dysmorphological findings [J].

Vianna, Fernanda S. L. ;

Schueler-Faccini, Lavinia ;

Leite, Julio Cesar L. ;

de Sousa, Silvia H. C. ;

da Costa, Lea Marcia M. ;

Dias, Murilo F. ;

Morelo, Elaine F. ;

Doriqui, Maria Juliana R. ;

Maximino, Claudia M. ;

Sanseverino, Maria Teresa V. .

CLINICAL DYSMORPHOLOGY, 2013, 22 (02) :59-63

[53] Pregnancy outcome after TNF-α inhibitor therapy during the first trimester: a prospective multicentre cohort study [J].

Weber-Schoendorfer, Corinna ;

Oppermann, Marc ;

Wacker, Evelin ;

Bernard, Nathalie ;

Beghin, Delphine ;

Cuppers-Maarschalkerweerd, Benedikte ;

Richardson, Jonathan L. ;

Rothuizen, Laura E. ;

Pistelli, Alessandra ;

Malm, Heli ;

Eleftheriou, Georgios ;

Kennedy, Debra ;

Duman, Mine Kadioglu ;

Meister, Reinhard ;

Schaefer, Christof .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 80 (04) :727-739

[54] 3,6′-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation [J].

Yoon, Jeong Seon ;

Lee, Jong-Hwan ;

Tweedie, David ;

Mughal, Mohamed R. ;

Chigurupati, Srinivasulu ;

Greig, Nigel H. ;

Mattson, Mark P. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2013, 91 (05) :671-680

← 1 2 3 4 5 6 →