Influence of Water-Miscible Ionic Liquid 1-Butyl-3-methylimidazolium Tetrafluoroborate [BMIM][BF4] on Acetylcholinesterase Inhibition-Based Spectrometric Assay for Parathion Methyl

被引:0
|
作者
Chen, Jin [1 ]
Miao, Jigen [1 ]
Qi, Xiaoxue [1 ]
Miao, Yuqing [1 ]
机构
[1] Zhejiang Normal Univ, Inst Phys Chem, Coll Chem & Life Sci, Jinhua 321004, Peoples R China
关键词
Ionic liquid; Acetylcholinesterase; 1-Butyl-3-methylimidazolium tetrafluoroborate; Organophosphorous; PARAOXON;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The influences of water-miscible ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) on acetylcholinesterase (AChE) inhibition-based organophosphorous assay were investigated. On the one hand. water-miscible [BMIM][BF4] competitively removes the essential hydration shell from the AChE molecule and thus enzyme activity is inhibited slightly. On the other hand, the existence of [BMIM][BF4] improves the inhibition binding between AChE and para-thion methyl. 5.1 % [BMIM][BF4] leds to the best inhibition rate. Ionic liquids mixed aqueous solutions show the potential to provide a promising and effective medium in organophosphorous assay with AChE.
引用
收藏
页码:4744 / 4748
页数:5
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