The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury

被引：13

作者：

Gong, Leilei ^{[1
]}

Zhu, Yun ^{[1
]}

Xu, Xi ^{[1
]}

Li, Huaiqin ^{[1
]}

Guo, Weimin ^{[1
]}

Zhao, Qin ^{[3
]}

Yao, Dengbing ^{[1
,2
]}

机构：

[1] Coinnovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, Nantong 226019, Jiangsu, Peoples R China

[2] Nantong Univ, Sch Life Sci, Nantong 226019, Jiangsu, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Key Lab Peoples Liberat Army, Beijing, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 24期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; peripheral nerve injury; Wallerian degeneration; sciatic nerve injury; Claudin; 14; rat; Schwann cell; Signal pathways; c-Jun; Akt; ERK1/2; NSFC grant; neural regeneration; TIGHT JUNCTION PROTEINS; SCHWANN-CELLS; FUNCTIONAL RECOVERY; C-JUN; EXPRESSION; MIGRATION;

D O I：

10.4103/1673-5374.147946

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0-4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt and ERK1/2 pathways. Further studies revealed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.

引用

页码：2151 / 2158

页数：8

共 36 条

[11] Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins [J].