New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis

被引：70

作者：

Lacret, Rodney ^{[1
]}

Oves-Costales, Daniel ^{[1
]}

Gomez, Cristina ^{[1
]}

Diaz, Caridad ^{[1
]}

de la Cruz, Mercedes ^{[1
]}

Perez-Victoria, Ignacio ^{[1
]}

Vicente, Francisca ^{[1
]}

Genilloud, Olga ^{[1
]}

Reyes, Fernando ^{[1
]}

机构：

[1] Fdn MEDINA, Ctr Excelencia Invest Med Innovadores Andalucia, Granada 18016, Spain

来源：

MARINE DRUGS | 2015年 / 13卷 / 01期

关键词：

Streptomyces zhaozhouensis; ikarugamycin; polycyclic tetramate macrolactams; antifungal; antibacterial; POLYCYCLIC TETRAMATE MACROLACTAMS; MARINE-DERIVED BACTERIUM; NATURAL-PRODUCT; DRUG DISCOVERY; METABOLITES; LACTAM;

D O I：

10.3390/md13010128

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

引用

页码：128 / 140

页数：13

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