HNF-4α:: from MODY to late-onset type 2 diabetes

被引：64

作者：

Gupta, RK

Kaestner, KH

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Penn Diabet Ctr, Philadelphia, PA 19104 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 11期

关键词：

D O I：

10.1016/j.molmed.2004.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4alpha in the human liver and islet, suggesting a very broad role for HNF-4alpha in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4alpha to the much more common late-onset type 2 diabetes.

引用

收藏

页码：521 / 524

页数：4

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