Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer

被引：7

作者：

Chen, Yuhong ^{[1
]}

Yang, Biao ^{[2
]}

Chen, Mingyang ^{[3
]}

Li, Zhaojun ^{[4
]}

Liao, Zhengyin ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, West China Med Sch, Dept Abodominal Oncol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, West China Med Sch, Dept Gastroentol, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Stomatol Hosp, Chengdu 610041, Sichuan, Peoples R China

[4] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Radiat Oncol, Haikou 570311, Hainan, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2022年 / 27卷 / 07期

关键词：

rectal cancer; biomarker; neoadjuvant chemoradiation; response; PATHOLOGICAL COMPLETE RESPONSE; PREOPERATIVE CHEMORADIATION THERAPY; HUMAN COLORECTAL-CANCER; COPY NUMBER ALTERATIONS; TUMOR RESPONSE; CHEMORADIOTHERAPY RESPONSE; MOLECULAR MARKERS; TEXTURE ANALYSIS; PROGNOSTIC VALUE; DNA METHYLATION;

D O I：

10.31083/j.fbl2707201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Locally advanced rectal cancer (RC) is treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery. Currently, organ-sparing approaches and/or "watch-and-wait" strategies other than unnecessary surgery have been suggested as the best option for patients who achieve complete regression after neoadjuvant treatment. However, patients respond differently to nCRT, hence the urgent need for effective methods to predict whether individual rectal cancer patients could benefit from this treatment. In this review, we summarize the biomarkers reported to be potential predictors of the therapeutic response of RC to nCRT. Biomarkers that are associated with genes, ribonucleic acid (RNA) and proteins are summarized and described first, followed by other types including immune and tumour microenvironment-related biomarkers, imaging biomarkers, microbiome-associated biomarkers, and blood-based biomarkers.

引用

页数：26

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