Dormant hypermethylated tumour suppressor genes: questions and answers

被引：76

作者：

Esteller, M ^{[1
]}

机构：

[1] Spanish Natl Canc Ctr CNIO, Mol Pathol Programme, Epigenet Lab, Madrid 28029, Spain

来源：

JOURNAL OF PATHOLOGY | 2005年 / 205卷 / 02期

关键词：

DNA methylation; epigenics; CpG island; tumor suppressor genes;

D O I：

10.1002/path.1707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epigenetic inactivation of tumour suppressor genes by promoter CpG island methylation is nowadays one of the hottest topics in cancer research. However, there are still several important open questions: Can we use CpG island hypermethylation to classify tumours according to their clinical behaviour and chemosensitivity? How do we prove that our hypermethylated gene is important for cancer development and/or progression? Which enzymes are directly responsible for the CpG island hypermethylation of tumour suppressor genes? How is the chromatin structure and molecular environment in and around the hypermethylated CpG islands? Can we wake up these dormant hypermethylated tumour suppressor genes in an epigenetic therapy of cancer? Some answers are provided in this review, but other questions remain unsolved, awaiting the eager epigenetic researcher. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.

引用

页码：172 / 180

页数：9

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