A chelate theory for the mechanism of action of aspirin-like drugs

被引：19
作者：
Wang, X [1 ]
机构：
[1] Cornell Univ, Coll Med, Dept Pathol, New York, NY 10021 USA
来源：
MEDICAL HYPOTHESES | 1998年 / 50卷 / 03期
关键词：
D O I：
10.1016/S0306-9877(98)90024-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an ever-increasing number of members, are an indispensable part of modern life. However, the question as to how these drugs work in the body has remained unsettled. It is postulated here that this group of drugs may exert their therapeutic (and adverse) effects by chelating various physiologically important metallic cations in the body. The chelate theory is supported by the vast majority, if not all, of the observations on these drugs made in the past.
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页码：239 / 251
页数：13
相关论文
共 131 条
[1]   THE MECHANISMS OF ACTION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].
ABRAMSON, SB ;
WEISSMANN, G .
ARTHRITIS AND RHEUMATISM, 1989, 32 (01) :1-9
[2]   MOLECULAR-INTERACTIONS IN MACROPHAGE ACTIVATION [J].
ADAMS, DO .
IMMUNOLOGY TODAY, 1989, 10 (02) :33-35
[3]   THE COMPLEX FORMATION BETWEEN IRON(III)ION AND SOME PHENOLS .2. SALICYLIC ACID AND PARA-AMINO SALICYLIC ACID [J].
AGREN, A .
ACTA CHEMICA SCANDINAVICA, 1954, 8 (06) :1059-1072
[4]   INSULIN ACTION IN ISOLATED FAT-CELLS .2. EFFECTS OF DIVALENT-CATIONS ON STIMULATION BY INSULIN OF PROTEIN-SYNTHESIS, ON INHIBITION OF LIPOLYSIS BY INSULIN, AND ON THE BINDING OF I-125-LABELED INSULIN TO ISOLATED FAT-CELLS [J].
AKHTAR, RA ;
PERRY, MC .
BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 585 (01) :117-127
[5]  
ATKINS E, 1979, FED PROC, V38, P57
[6]  
Atkinson T, 1992, INFLAMMATION BASIC P, P193
[7]  
BABKO AK, 1947, ZH OBSHCH KHIM+, V17, P443
[8]  
BABKO AK, 1945, ZH OBSHCH KHIM, V15, P745
[9]  
Baker, 1936, NATURE, V137, P236, DOI 10.1038/137236a0
[10]   A POLAROGRAPHIC INVESTIGATION OF IRON SULFOSALICYLATE COMPLEX IONS [J].
BANKS, CV ;
PATTERSON, JH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (07) :3062-3064
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