Side-chain hydrophobicity controls the activity of proton channel forming rigid rod-shaped polyols

被引:42
作者
Ni, CY [1 ]
Matile, S [1 ]
机构
[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA
关键词
D O I
10.1039/a708841h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Increased activity, facile incorporation into lipid bilayers and intact active structure and transport selectivity are the consequences of modifications of the side-chain hydrophobicity of a proton channel-forming octa(p-phenylene).
引用
收藏
页码:755 / 756
页数:2
相关论文
共 9 条
[1]   ONE-SIDED ACTION OF AMPHOTERICIN-B ON CHOLESTEROL-CONTAINING MEMBRANES IS DETERMINED BY ITS SELF-ASSOCIATION IN THE MEDIUM [J].
BOLARD, J ;
LEGRAND, P ;
HEITZ, F ;
CYBULSKA, B .
BIOCHEMISTRY, 1991, 30 (23) :5707-5715
[2]   Synthetic organic chemical models for transmembrane channels [J].
Gokel, GW ;
Murillo, O .
ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (09) :425-432
[3]  
Ladokhin AS, 1997, METHOD ENZYMOL, V278, P462
[4]   A synthetic transmembrane channel active in lipid bilayers [J].
Meillon, JC ;
Voyer, N .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (09) :967-969
[5]   HYDROGEN-BONDED CHAIN MECHANISMS FOR PROTON CONDUCTION AND PROTON PUMPING [J].
NAGLE, JF ;
TRISTRAMNAGLE, S .
JOURNAL OF MEMBRANE BIOLOGY, 1983, 74 (01) :1-14
[6]   Toward biomimetic ion channels formed by rigid-rod molecules: Length-dependent ion-transport activity of substituted oligo(p-phenylene)s [J].
Sakai, N ;
Brennan, KC ;
Weiss, LA ;
Matile, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (37) :8726-8727
[7]   THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION - A NEW LIGAND CLASS AND A PROCESS IMPROVEMENT [J].
SHARPLESS, KB ;
AMBERG, W ;
BENNANI, YL ;
CRISPINO, GA ;
HARTUNG, J ;
JEONG, KS ;
KWONG, HL ;
MORIKAWA, K ;
WANG, ZM ;
XU, DQ ;
ZHANG, XL .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (10) :2768-2771
[8]   Oligo-THF peptides: Synthesis, membrane insertion, and studies of ion channel activity [J].
Wagner, H ;
Harms, K ;
Koert, U ;
Meder, S ;
Boheim, G .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (22) :2643-2646
[9]   Rigid rod-shaped polyols: Functional nonpeptide models for transmembrane proton channels [J].
Weiss, LA ;
Sakai, N ;
Ghebremariam, B ;
Ni, CY ;
Matile, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (50) :12142-12149