Asymmetric hydrogenation of ketones catalyzed by a ruthenium(II)-indan-ambox complex

被引：44

作者：

Li, Wei ^{[1
,2
,3
]}

Hou, Guohua ^{[1
,2
]}

Wang, Chunjiang ^{[3
]}

Jiang, Yutong ^{[3
]}

Zhang, Xumu ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 22期

基金：

美国国家卫生研究院;

关键词：

HIGHLY ENANTIOSELECTIVE HYDROGENATION; AROMATIC KETONES; STEREOSELECTIVE HYDROGENATION; RHODIUM(I) AMIDES; C=N BONDS; EFFICIENT; LIGAND; REDUCTION; MECHANISM; ALCOHOLS;

D O I：

10.1039/b927028k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S,R)-Indan-ambox ligand and its ruthenium(II) complex have been prepared and successfully applied to asymmetric hydrogenation of prochiral simple ketones. A wide range of unfunctionalized ketones are reduced by Ru(II)-indan-ambox catalyst with excellent enantioselectivities (up to 97% ee).

引用

页码：3979 / 3981

页数：3

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