Effect of Vitamin D supplementation on reduction in levels of HbA1 in patients recently diagnosed with type 2 Diabetes Mellitus having asymptomatic Vitamin D deficiency

被引:16
|
作者
Randhawa, Fawad Ahmad [1 ]
Mustafa, Saqib [1 ]
Khan, Dur Muhammad [1 ]
Hamid, Shahid [1 ]
机构
[1] King Edward Med Univ, Dept Med, Lahore, Pakistan
关键词
Blood sugar level; Metformin; Type II diabetes mellitus; HbA1c; Vitamin D supplementation; RISK;
D O I
10.12669/pjms.334.12288
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To study the effect of Vitamin D supplementation on reduction in level of HbA1 in patients recently diagnosed with diabetes mellitus Type II having asymptomatic Vitamin D deficiency. Methods: This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore for 6 months from January 01 2016 to June 30, 2016. 114 Patients were included through non probability purposive sampling technique. Informed consent and demographic information was collected. Patients were divided in two groups by randomization through tossing a coin. GroupA patients received Metformin tablet alone at 500 mg after dinner and Group-B patients were treated with same dosage of Metformin along with oral vitamin D at 200,000 IU monthly for three months. Blood sample was obtained at baseline, 3 months and 6 months of initiation of therapy. All samples were sent to the laboratory for complete blood count, blood sugar fasting, serum calcium, serum phosphorous, serum alkaline phosphatase, HbA1c and serum 25 Hyroxy Vitamin D (S-25(OH) D) levels and iPTH. Data entry and analysis was done by using SPSS 20. Results: The mean age of patients in metformin group was 42.37 +/- 4.59 years while mean age of patients in combination group was 43.33 +/- 4.86years. Males were 45.6% and females were 54.4% in metformin group while in combination group, 36.8% were males' and 63.2% were females'. At baseline, in metformin group, mean Vitamin D level was 17.09 +/- 1.73mg/dl and in combination group, mean Vitamin D level was 16.49 +/- 1.56mg/dl. The difference was insignificant (p > 0.05). On 2nd visit, combination group mean Vitamin D was 29.04 +/- 3.96mg/dl. At baseline, 1st and 2nd visit, in metformin group, mean HbA1c was 7.59 +/- 0.47%, 7.46 +/- 0.25% and 7.30 +/- 0.29%. At baseline, 1st and 2nd visit, in combination group, mean HbA1c was 7.71 +/- 0.19%, 7.57 +/- 0.21% and 7.43 +/- 0.26%. The difference was insignificant (p > 0.05) at baseline while significant on later follow-ups (P < 0.05). Conclusion: Vitamin D supplementation improved the glycemic control but substantial reduction in HbA1c was statistically insignificant in both groups.
引用
收藏
页码:881 / 885
页数:5
相关论文
共 50 条
  • [41] Vitamin D deficiency is common among Polish children with newly diagnosed type 1 diabetes mellitus
    Klenczar-Kciuk, Karolina
    Seget, Sebastian
    Adamczyk, Piotr
    Jarosz-Chobot, Przemyslawa
    ENDOKRYNOLOGIA POLSKA, 2025, 76 (01) : 59 - 65
  • [42] Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency
    Manuel Ramiro-Lozano, Jose
    Maria Calvo-Romero, Jose
    THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, 2015, 6 (06) : 245 - 248
  • [43] Effect of vitamin D supplementation on bone resorption in patients with type 2 diabetes
    Angellotti, Edith
    Pittas, Anastassios G.
    Ceglia, Lisa
    JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 : 216 - 216
  • [44] Effect of vitamin D supplementation in type 2 diabetes patients with pulmonary tuberculosis
    Kota, Sunil Kumar
    Jammula, Sruti
    Kota, Siva Krishna
    Tripathy, Prabhas Ranjan
    Panda, Sandip
    Modi, Kirtikumar D.
    DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2011, 5 (02) : 85 - 89
  • [45] Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus
    Akhter, Asma
    Alouffi, Sultan
    Shahab, Uzma
    Akasha, Rihab
    Fazal-Ur-Rehman, Mohd
    Ghoniem, Mohamed E.
    Ahmad, Naved
    Kaur, Kirtanjot
    Pandey, Ramendra Pati
    Alshammari, Ahmed
    Akhter, Firoz
    Ahmad, Saheem
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2024, 753
  • [46] Vitamin D and Type 2 diabetes mellitus
    Xuan, Yan
    Zhao, Hong-yan
    Liu, Jian-Min
    JOURNAL OF DIABETES, 2013, 5 (03) : 261 - 267
  • [47] Vitamin D and Type 2 Diabetes Mellitus
    Issa, Claire Michael
    ULTRAVIOLET LIGHT IN HUMAN HEALTH, DISEASES AND ENVIRONMENT, 2017, 996 : 193 - 205
  • [48] Vitamin D and type 2 diabetes mellitus
    Cangoz, S.
    Chang, Y. -Y.
    Chempakaseril, S. J.
    Guduru, R. C.
    Huynh, L. M.
    John, J. S.
    John, S. T.
    Joseph, M. E.
    Judge, R.
    Kimmey, R.
    Kudratov, K.
    Lee, P. J.
    Madhani, I. C.
    Shim, P. J.
    Singh, S.
    Singh, S.
    Ruchalski, C.
    Raffa, R. B.
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2013, 38 (02) : 81 - 84
  • [49] Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study
    Angellotti, Edith
    D'Alessio, David
    Dawson-Hughes, Bess
    Nelson, Jason
    Cohen, Robert M.
    Gastaldelli, Amalia
    Pittas, Anastassios G.
    JOURNAL OF THE ENDOCRINE SOCIETY, 2018, 2 (04): : 310 - 321
  • [50] VITAMIN D LEVELS AND BONE METABOLISM IN ADULT PATIENTS WITH TYPE 1 DIABETES MELLITUS
    Barmpa, E.
    Tigas, S.
    Koukoulis, G. N.
    Bargiota, A.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2020, 22 : A239 - A240