The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells

被引:123
作者
Gimenez-Arnau, Ana M. [1 ]
DeMontojoye, Laurence [2 ,3 ]
Asero, Riccardo [4 ]
Cugno, Massimo [5 ]
Kulthanan, Kanokvalai [6 ]
Yanase, Yuhki [7 ]
Hide, Michihiro [8 ]
Kaplan, Allen P. [9 ]
机构
[1] Univ Autonoma Barcelona, Inst Mar Invest Med, Hosp Mar, Dept Dermatol, Barcelona, Spain
[2] Catholic Univ Louvain, Clin Univ St Luc, Dept Dermatol, Louvain La Neuve, Belgium
[3] Catholic Univ Louvain, Inst Expt Clin Res, Pneumol ENT & Dermatol Pole, Louvain La Neuve, Belgium
[4] Clin San Carlo, Ambulatorio Allergol, Paderno Dugnano, Italy
[5] Univ Milan, Dipartmento Fisiopatol Med Chirurg & Trapianti, Med Intema, IRCCS Fdn Ca Granda Osped Maggiore Policlin, Milan, Italy
[6] Mahidol Univ, Dept Dermatol, Siriraj Hosp, Fac Med, Bangkok, Thailand
[7] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Hiroshima, Japan
[8] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Dermatol, Hiroshima, Japan
[9] Med Univ South Carolina, Dept Med, Div Pulm & Crit Care Med & Allergy & Immunol, Charleston, SC 29425 USA
关键词
Lymphocyte; Eosinophil; Basophil; Endothelial cell; Neuroinflammation; CHRONIC IDIOPATHIC URTICARIA; FC-EPSILON-RI; ENDOTHELIAL GROWTH-FACTOR; AFFINITY IGE RECEPTOR; HUMAN MAST-CELLS; GENE-RELATED PEPTIDE; SERUM SKIN-TEST; HISTAMINE-RELEASE; DISEASE-ACTIVITY; TISSUE FACTOR;
D O I
10.1016/j.jaip.2021.03.033
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular infiltrate around small venules of the skin. It consists primarily of CD4(D) lymphocytes, a prominence of the T helper (Th)2 subtype but also Th1 cells, with Th17 cell-derived cytokines elevated in plasma. There are also neutrophils, eosinophils, basophils, and monocytes. Chemokines derived from mast cells and activated endothelial cells drive the process. Although the role of the cellular infiltrate has not previously been addressed, each constituent can contribute to the overall pathogenesis. It is of interest that CSU responds to corticosteroid, yet, short-term steroids do not affect autoimmunity or degranulation of mast cells, and act on margination of cells along the endothelium and chemotaxis to enter the surrounding dermis. In this review, we address each cell's contribution to the overall inflammatory response, as it is currently understood, with a view toward development of therapeutic options that impede the function of critical cells and/or their secretory products. (C) 2021 American Academy of Allergy, Asthma & Immunology
引用
收藏
页码:2195 / 2208
页数:14
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