Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus

被引：78
作者：
Hundt, K
Martin, D
Hammer, E
Jonas, U
Kindermann, MK
Schauer, F
机构：
[1] Ernst Moritz Arndt Univ Greifswald, Inst Microbiol & Mol Biol, D-17487 Greifswald, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Inst Chem & Biochem, D-17487 Greifswald, Germany
[3] Sudzucker AG Mannheim, Ochsenfurt, ZAFES, D-67283 Obrigheim, Germany
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2000年 / 66卷 / 09期
关键词：
D O I：
10.1128/AEM.66.9.4157-4160.2000
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We investigated the ability of Trametes versicolor and Pycnoporous cinnabarinus to metabolize triclosan. T. versicolor produced three metabolites, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-xylopyranoside, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-glucopyranoside, and 2,4-dichlorophenol. P. cinnabarinus converted triclosan to 2,2,4'-trichloro-2'-methoxydiphenyl ether and the glucoside conjugate known from T. versicolor. The conjugates showed a distinctly lower cytotoxic and microbicidal activity than triclosan did.
引用
收藏
页码：4157 / 4160
页数：4
相关论文
共 36 条
  • [1] ARFMANN HA, 1993, Z NATURFORSCH C, V48, P52
  • [2] Backer H.J., 1956, ORG SYNTH, P14
  • [3] Triclosan: Applications and safety
    Bhargava, HN
    Leonard, PA
    [J]. AMERICAN JOURNAL OF INFECTION CONTROL, 1996, 24 (03) : 209 - 218
  • [4] PERCUTANEOUS ABSORPTION AND METABOLISM OF IRGASAN DP300
    BLACK, JG
    HOWES, D
    RUTHERFORD, T
    [J]. TOXICOLOGY, 1975, 3 (01) : 33 - 47
  • [5] Initial oxidative and subsequent conjugative metabolites produced during the metabolism of phenanthrene by fungi
    Casillas, RP
    Crow, SA
    Heinze, TM
    Deck, J
    Cerniglia, CE
    [J]. JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1996, 16 (04): : 205 - 215
  • [6] IDENTIFICATION OF A NOVEL METABOLITE IN PHENANTHRENE METABOLISM BY THE FUNGUS CUNNINGHAMELLA-ELEGANS
    CERNIGLIA, CE
    CAMPBELL, WL
    FREEMAN, JP
    EVANS, FE
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (09) : 2275 - 2279
  • [7] COX AR, 1987, J SOC COSMET CHEM, V38, P223
  • [8] DeSalva S J, 1989, Am J Dent, V2 Spec No, P185
  • [9] Hammer E, 1998, APPL ENVIRON MICROB, V64, P2215
  • [10] Transformation of diphenyl ethers by Trametes versicolor and characterization of ring cleavage products
    Hundt, K
    Jonas, U
    Hammer, E
    Schauer, F
    [J]. BIODEGRADATION, 1999, 10 (04) : 279 - 286
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