Association models for binding of molecules to nanostructures

被引：30

作者：

Ahumada, Manuel ^{[1
]}

Lissi, Eduardo ^{[2
]}

Montagut, Ana Maria ^{[1
]}

Valenzuela-Henriquez, Francisco ^{[3
]}

L. Pacioni, Natalia ^{[4
,5
]}

Alarcon, Emilio I. ^{[1
,6
]}

机构：

[1] Univ Ottawa, Heart Inst, Div Cardiac Surg, Bionanomat Chem & Engn Lab, 40 Ruskin St,Rm H5229, Ottawa, ON, Canada

[2] Univ Santiago Chile, Fac Quim & Biol, Lab Cinet & Fotoquim, Dept Ciencias Ambiente, Ave Libertador Bernardo OHiggins 3363, Santiago, Chile

[3] Pontificia Univ Catolica Valparaiso, Inst Matemat, Blanco Viel 596, Valparaiso, Chile

[4] INFIQC CONICET, Haya Torre & Medina Allende S-N,X5000HUA, Cordoba, Spain

[5] Univ Nacl Cordoba, Dept Quim Organ, Fac Ciencias Quim, Haya Torre & Medina Allende S-N,X5000HUA, Cordoba, Spain

[6] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1Y 4W7, Canada

来源：

ANALYST | 2017年 / 142卷 / 12期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BOVINE SERUM-ALBUMIN; ISOTHERMAL TITRATION CALORIMETRY; COATED GOLD NANOPARTICLES; SILVER NANOPARTICLES; METAL NANOCLUSTERS; MAGNETIC FLUIDS; PROTEIN; FLUORESCENCE; CONSTANT; FUNCTIONALIZATION;

D O I：

10.1039/c7an00288b

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The interaction between nanoparticles and molecules plays a key role in determining the activity and performance of a given nanostructure. These interactions are pivotal for a variety of applications including drug delivery, surface manipulation for targeted therapies, and catalysis. However, to this day, gathering precise association parameters for the interaction of the molecules with nanostructures remains elusive and mostly imprecise. In this review, we present a critical discussion of the most commonly used techniques and models intended for determining the association of molecules with nanoparticles. Particular emphasis has been put on discussing the limitations and pitfalls related to determining association constants in this tutorial review.

引用

页码：2067 / 2089

页数：23

共 88 条

[1] Interactions of Bacterial Lipopolysaccharides with Gold Nanorod Surfaces Investigated by Refractometric Sensing [J].