Base- and Copper-Catalyzed Intramolecular Cyclization for the Direct Synthesis of Dihydrofurans

被引：30

作者：

Chen, Yong-Fei ^{[1
]}

Wang, Hai-Fei ^{[1
]}

Wang, Ya ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Zhu, Hai-Liang ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 07期

关键词：

alkynes; copper; cyclization; dihydrofurans; furans; HIGHLY EFFICIENT SYNTHESIS; SUBSTITUTED FURANS; COUPLING REACTIONS; C-N; 1,3-DICARBONYL COMPOUNDS; PROPARGYLIC ALCOHOLS; FACILE SYNTHESIS; PALLADIUM; CYCLOISOMERIZATION; ANNULATION;

D O I：

10.1002/adsc.201000005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and convenient synthetic approach to dihydrofurans has been developed from the cyclization of 2-propynyl-1,3-dicarbonyl compounds catalyzed by potassium tert-butoxide, copper(II) trifluoromethanesulfonate and triphenylphosphine using methanol/dichloromethane as the solvent under very mild conditions. Moreover, dihydrofurans could be easily transformed into the corresponding furans in the presence of trifluoroacetic acid.

引用

页码：1163 / 1168

页数：6

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