Piribedil-selective electrodes based on Bi(III)-iodide and Hg(II)-iodide complexes

被引：8

作者：

Abdel-Gawad, FM ^{[1
]}

Issa, YM

Hassouna, MEM

Hussien, EM

机构：

[1] Natl Org Drug Control & Res, Giza, Egypt

[2] Cairo Univ, Fac Sci, Giza, Egypt

[3] Cairo Univ, Fac Sci, Beni Suef Branch, Bani Suwayf, Egypt

来源：

MICROCHIMICA ACTA | 2003年 / 141卷 / 1-2期

关键词：

piribedil; ion-selective electrode; PVC membrane; potentiometric determination; biological fluids;

D O I：

10.1007/s00604-002-0917-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We describe new ion-selective electrodes for piribedil (PD) based on Bi(III)-iodide or Hg(II)-iodide piribedil ion associate complexes in a poly(vinyl chloride) (PVC) membrane with dibutylphthalate (DBP) and dioctylphthalate (DOP) as plasticizing solvent mediator. The electrodes (PD-[BiI4]/DBP, PD-[BiI4]/DOP, PD2-[HgI4]/DBP and PD2-[HgI4]/DOP) show nearly Nernstian response over the concentration range 2 x 10(-5)-10(-2)M of the drug. The working pH ranges were 3.1-6.0, 3.5-6.0, 3.0-6.0 and 3.5-6.4, and the isothermal coefficients of the cells were 0.00113, 0.00146, 0.00059 and 0.00120 V/degreesC for PD-[BiI4]/DBP, PD-[BiI4]/DOP, PD2-[HgI4]/DBP and PD2-[HgI4]/DOP, respectively. The selectivity coefficients for numerous compounds are given. The electrodes have been used for the direct determination of PD in pure form and in tablets or in biological fluids by the standard addition and potentiometric titration methods.

引用

页码：7 / 13

页数：7

共 14 条

[1] Ion-pair formation of Bi(III)-iodide with some nitrogenous drugs and its application to pharmaceutical preparations [J].