Extracellular adenosine: a critical signal in liver fibrosis

被引：17

作者：

Fausther, Michel ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Internal Med, Div Gastroenterol & Hepatol, 4301 W Markham St,Mail Slot 567,Shorey S8-68, Little Rock, AR 72205 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2018年 / 315卷 / 01期

关键词：

extracellular adenosine; G protein-coupled receptor; hepatic fibrosis; liver myofibroblasts; purinergic signaling; HEPATIC STELLATE CELLS; ACETALDEHYDE-INDUCED ACTIVATION; PROTEIN-KINASE-A; A(2B) RECEPTORS; RAT-LIVER; ANTIINFLAMMATORY MECHANISM; INTERNATIONAL UNION; A(2A) RECEPTORS; INFLAMED SITES; UP-REGULATION;

D O I：

10.1152/ajpgi.00006.2018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Extracellular adenosine nucleoside is a potent, endogenous mediator that signals through specific G protein-coupled receptors, and exerts pleiotropic effects on liver physiology, in health and disease. Particularly, adenosinergic or adenosine-mediated signaling pathways impact the progression of hepatic fibrosis, a common feature of chronic liver diseases, through regulation of matrix deposition by liver myofibroblasts. This review examines the current lines of evidence on adenosinergic regulation of liver fibrosis and myofibroblasts, identifies unanswered research questions, and proposes important future areas of investigation.

引用

页码：G12 / G19

页数：8

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