Resistance of herpes simplex virus type 1 to acyclovir: Thymidine kinase gene mutagenesis study

被引：19
|
作者：
Frobert, Emilie
Ooka, Tadamasa
Cortay, Jean-Claude
Lina, Bruno
Thouvenot, Danielle
Morfin, Florence
机构：
[1] Hospices Civils Lyon, Lab Virol Est, F-69373 Lyon 08, France
[2] Univ Lyon 1, Fac Med Laennec, CNRS,UMR 5537, Lab Virol & Pathogenese Virale, F-69372 Lyon, France
来源：
ANTIVIRAL RESEARCH | 2007年 / 73卷 / 02期
关键词：
herpes simplex virus; ACV resistance; thymidine kinase; site-directed mutagenesis;
D O I：
10.1016/j.antiviral.2006.08.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
By site-directed mutagenesis, we investigate the role of six mutations of herpes simplex virus type 1 thymidine kinase (TK) gene in the acquisition of resistance to acyclovir (ACV). TK activity was not impaired by substitutions located at codons 17, 161 and 374 and these mutations were thus related to TK gene polymorphism. Mutations His 105Pro, Leu364Pro and Asp 162Ala lead to the loss of TK activity that could result in ACV-resistance. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 150
页数：4
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