Resistance of herpes simplex virus type 1 to acyclovir: Thymidine kinase gene mutagenesis study

被引：19
|
作者：
Frobert, Emilie
Ooka, Tadamasa
Cortay, Jean-Claude
Lina, Bruno
Thouvenot, Danielle
Morfin, Florence
机构：
[1] Hospices Civils Lyon, Lab Virol Est, F-69373 Lyon 08, France
[2] Univ Lyon 1, Fac Med Laennec, CNRS,UMR 5537, Lab Virol & Pathogenese Virale, F-69372 Lyon, France
来源：
ANTIVIRAL RESEARCH | 2007年 / 73卷 / 02期
关键词：
herpes simplex virus; ACV resistance; thymidine kinase; site-directed mutagenesis;
D O I：
10.1016/j.antiviral.2006.08.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
By site-directed mutagenesis, we investigate the role of six mutations of herpes simplex virus type 1 thymidine kinase (TK) gene in the acquisition of resistance to acyclovir (ACV). TK activity was not impaired by substitutions located at codons 17, 161 and 374 and these mutations were thus related to TK gene polymorphism. Mutations His 105Pro, Leu364Pro and Asp 162Ala lead to the loss of TK activity that could result in ACV-resistance. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 150
页数：4
相关论文
共 50 条
  • [21] Acyclovir resistance in herpes simplex virus type I encephalitis: a case report
    Sauerbrei, Andreas
    JOURNAL OF NEUROVIROLOGY, 2017, 23 (04) : 638 - 639
  • [22] INFECTIVITY AND REPLICATION INHIBITION EFFECT OF 5-FLUOROURACIL ON HERPES SIMPLEX VIRUS TYPE-1 ASSOCIATED WITH MUTATIONS IN THYMIDINE KINASE GENE
    Taskin, Mehmet Hakan
    Kurucay, Hanne Nur
    Kadi, Hamza
    Tamer, Cuneyt
    Ozan, Emre
    Muftuoglu, Bahadir
    Albayrak, Harun
    Gumusova, Semra
    Igde, Mahir
    Elhag, Ahmed Eisa
    Yazici, Zafer
    FARMACIA, 2022, 70 (06) : 1105 - 1113
  • [23] Herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus
    Hiller, C
    Tamgüney, G
    Stolte, N
    Mätz-Rensing, K
    Lorenzen, D
    Hör, S
    Thurau, M
    Wittmann, S
    Slavin, S
    Fickenscher, H
    VIROLOGY, 2000, 278 (02) : 445 - 455
  • [24] Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells
    Hsia, Shao-Chung V.
    Pinnoji, Rajeswara C.
    Bedadala, Gautam R.
    Hill, James M.
    Palem, Jayavardhana R.
    JOURNAL OF NEUROVIROLOGY, 2010, 16 (01) : 13 - 24
  • [25] Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy
    Blasberg, RG
    Tjuvajev, JG
    QUARTERLY JOURNAL OF NUCLEAR MEDICINE, 1999, 43 (02): : 163 - 169
  • [26] Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells
    Shao-Chung V. Hsia
    Rajeswara C. Pinnoji
    Gautam R. Bedadala
    James M. Hill
    Jayavardhana R. Palem
    Journal of NeuroVirology, 2010, 16 : 13 - 24
  • [27] Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 gs homopolymer repeat of the thymidine kinase gene
    Morfin, F
    Thouvenot, D
    Aymard, M
    Souillet, G
    JOURNAL OF MEDICAL VIROLOGY, 2000, 62 (02) : 247 - 250
  • [28] ANALYSIS OF THE RELATIONSHIP BETWEEN CELLULAR THYMIDINE KINASE-ACTIVITY AND VIRULENCE OF THYMIDINE KINASE-NEGATIVE HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2
    SUZUTANI, T
    KOYANO, S
    TAKADA, M
    YOSHIDA, I
    AZUMA, M
    MICROBIOLOGY AND IMMUNOLOGY, 1995, 39 (10) : 787 - 794
  • [29] Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes
    Sergerie, Yan
    Boivin, Guy
    ANTIVIRAL RESEARCH, 2008, 77 (01) : 77 - 80
  • [30] Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir
    Gambhir, SS
    Barrio, JR
    Wu, L
    Iyer, M
    Namavari, M
    Satyamurthy, N
    Bauer, E
    Parrish, C
    MacLaren, DC
    Borghei, AR
    Green, LA
    Sharfstein, S
    Berk, AJ
    Cherry, SR
    Phelps, ME
    Herschman, HR
    JOURNAL OF NUCLEAR MEDICINE, 1998, 39 (11) : 2003 - 2011
12345