Synthesis of (S)-(-)-Propranolol by Using Cs2.5H0.5PW12O40 Nanocatalyst as Green, Eco-Friendly, Reusable, and Recyclable Catalyst

被引：4

作者：

Gharib, Ali ^{[1
,2
]}

Jahangir, Manouchehr ^{[1
]}

Roshani, Mina ^{[1
]}

Pesyan, Nader Noroozi ^{[3
]}

Scheeren, J. W. ^{[4
]}

Mohadesazadeh, Sara ^{[2
]}

Lagzian, Shirin ^{[2
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Mashhad, Iran

[2] Agr Res & Serv Ctr, Mashhad, Iran

[3] Urmia Univ, Dept Chem, Fac Sci, Orumiyeh, Iran

[4] Radboud Univ Nijmegen, Dept Organ Chem, Cluster Mol Chem, NL-6525 ED Nijmegen, Netherlands

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2015年 / 45卷 / 03期

关键词：

catalyst; (S)-(-)-propranolol; reusable; heteropolyacid; nanoparticles; recyclable; cesium heteropolytungstate; HETEROPOLY ACIDS; OXIDATION; COMPLEXES;

D O I：

10.1080/15533174.2013.832323

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Cs2.5H0.5PW12O40 nanoparticle catalyst appear to be a new and efficient solid acid catalyst for an economical, environmentally benign synthesis of (S)-(-)-propranolol. Cs2.5H0.5PW12O40 nanocatalyst are used as a new, recyclable and reusable. Synthesis of (S)-(-)-propranolol is carried out in two steps with usual reagents: heteropolyacid, (+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate alpha-naphthyl glycidyl ether with high optical and chemical yield. With this synthesis, we have two products in the first reaction and it is not necessary to purify the crude oil. This by-product is removed in the second step by extraction and yield is satisfactory. The nanocatalyst of Cs2.5H0.5PW12O40 catalyzed the synthesis of propranolol in high yields and good selectivity.

引用

页码：350 / 355

页数：6

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