Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women

被引：1
作者：
Zhao, J. J. [1 ]
Feng, D. H. [1 ]
Cheng, L. [1 ]
Lu, T. [1 ]
Wang, L. [1 ]
机构：
[1] Wuxi Peoples Hosp, Dept Orthoped, Wuxi, Jiangsu, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 03期
关键词：
Osteoprotegerin gene; Genetic variants; Osteoporosis; Bone mineral density; VITAMIN-D-RECEPTOR; OSTEOPROTEGERIN GENE; OSTEOPOROTIC FRACTURES; LYS3ASN POLYMORPHISM; COMMERCIAL CATTLE; PROMOTER; RISK; EPIDEMIOLOGY; DIAGNOSIS; MASS;
D O I：
10.4238/2014.March.24.16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this study was to investigate the association of the g.27667T> A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy X-ray absorptiometry. The g.27667T>A genetic variant was genotyped using created restriction site-polymerase chain reaction. Our data indicated significant differences in BMD of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes. Individuals with the genotype TT had significantly higher BMDs than those of genotypes TA and AA (P < 0.05). Results from this study suggest that the g.27667T>A genetic variant in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women.
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页码：7332 / 7338
页数：7
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