ASGS: an alternative splicing graph web service

被引:10
作者
Bollina, Durgaprasad
Lee, Bernett T. K.
Tan, Tin Wee
Ranganathan, Shoba [1 ]
机构
[1] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia
[2] Macquarie Univ, Biotechnol Res Inst, Sydney, NSW 2109, Australia
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 119260, Singapore
关键词
GENOME; DATABASE; GENES;
D O I
10.1093/nar/gkl268
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alternative transcript diversity manifests itself a prime cause of complexity in higher eukaryotes. The Alternative Splicing Graph Server ( ASGS) is a web service facilitating the systematic study of alternatively spliced genes of higher eukaryotes by generating splicing graphs for the compact visual representation of transcript diversity from a single gene. Taking a set of transcripts in General Feature Format as input, ASGS identifies distinct reference and variable exons, generates a transcript splicing graph, an exon summary, splicing events classification and a single line graph to facilitate experimental analysis. This freely available web service can be accessed at http://asgs.biolinfo.org.
引用
收藏
页码:W444 / W447
页数:4
相关论文
共 16 条
  • [1] Common intervals and sorting by reversals: a marriage of necessity
    Bergeron, A
    Heber, S
    Stoye, J
    [J]. BIOINFORMATICS, 2002, 18 : S54 - S63
  • [2] BOLLINA D, 2005, 7 INT C INF INT WEB, V2, P759
  • [3] Finishing the euchromatic sequence of the human genome
    Collins, FS
    Lander, ES
    Rogers, J
    Waterston, RH
    [J]. NATURE, 2004, 431 (7011) : 931 - 945
  • [4] Gene finding in the chicken genome
    Eyras, E
    Reymond, A
    Castelo, R
    Bye, JM
    Camara, F
    Flicek, P
    Huckle, EJ
    Parra, G
    Shteynberg, DD
    Wyss, C
    Rogers, J
    Antonarakis, SE
    Birney, E
    Guigo, R
    Brent, MR
    [J]. BMC BIOINFORMATICS, 2005, 6 (1)
  • [5] WHY GENES IN PIECES
    GILBERT, W
    [J]. NATURE, 1978, 271 (5645) : 501 - 501
  • [6] Alternative splicing: A new drug target of the post-genome era
    Hagiwara, M
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2): : 324 - 331
  • [7] HOLLYWOOD: a comparative relational database of alternative splicing
    Holste, Dirk
    Huo, George
    Tung, Vivian
    Burge, Christopher B.
    [J]. NUCLEIC ACIDS RESEARCH, 2006, 34 : D56 - D62
  • [8] Sol-gel approach to Sr2CeO4 phosphor from single alkoxide precursors
    Kim, H
    Kim, YT
    Chae, HK
    [J]. JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2005, 33 (01) : 75 - 80
  • [9] DEDB:: a database of Drosophila melanogaster exons in splicing graph form -: art. no. 189
    Lee, BTK
    Tan, TW
    Ranganathan, S
    [J]. BMC BIOINFORMATICS, 2004, 5 (1)
  • [10] Bioinformatics analysis of alternative splicing
    Lee, C
    Wang, Q
    [J]. BRIEFINGS IN BIOINFORMATICS, 2005, 6 (01) : 23 - 33